Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred

12 Issues per year


IMPACT FACTOR 2016: 3.273

CiteScore 2016: 3.01

SCImago Journal Rank (SJR) 2016: 1.679
Source Normalized Impact per Paper (SNIP) 2016: 0.800

Online
ISSN
1437-4315
See all formats and pricing
More options …
Volume 390, Issue 11 (Nov 2009)

Issues

The epigenetic bottleneck of neurodegenerative and psychiatric diseases

Farahnaz Sananbenesi
  • Laboratory for Aging and Cognitive Diseases, European Neuroscience Institute, Grisebach Str. 5, D-37077 Göttingen, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Andre Fischer
  • Laboratory for Aging and Cognitive Diseases, European Neuroscience Institute, Grisebach Str. 5, D-37077 Göttingen, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2009-09-13 | DOI: https://doi.org/10.1515/BC.2009.131

Abstract

The orchestrated expression of genes is essential for the development and survival of every organism. In addition to the role of transcription factors, the availability of genes for transcription is controlled by a series of proteins that regulate epigenetic chromatin remodeling. The two most studied epigenetic phenomena are DNA methylation and histone-tail modifications. Although a large body of literature implicates the deregulation of histone acetylation and DNA methylation with the pathogenesis of cancer, recently epigenetic mechanisms have also gained much attention in the neuroscientific community. In fact, a new field of research is rapidly emerging and there is now accumulating evidence that the molecular machinery that regulates histone acetylation and DNA methylation is intimately involved in synaptic plasticity and is essential for learning and memory. Importantly, dysfunction of epigenetic gene expression in the brain might be involved in neurodegenerative and psychiatric diseases. In particular, it was found that inhibition of histone deacetylases attenuates synaptic and neuronal loss in animal models for various neurodegenerative diseases and improves cognitive function. In this article, we will summarize recent data in the novel field of neuroepigenetics and discuss the question why epigenetic strategies are suitable therapeutic approaches for the treatment of brain diseases.

Keywords: Alzheimer's disease; epigenetics; HDAC inhibitors; histone acetylation; learning and memory; neurodegenerative diseases

About the article

Corresponding author


Received: 2009-05-15

Accepted: 2009-08-07

Published Online: 2009-09-13

Published in Print: 2009-11-01


Citation Information: Biological Chemistry, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2009.131.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Katharina Braun, Jörg Bock, Tamar Wainstock, Emmanuel Matas, Inna Gaisler-Salomon, Jörg Fegert, Ute Ziegenhain, and Menahem Segal
Neuroscience & Biobehavioral Reviews, 2017
[2]
Jamie M. Kramer, Korinna Kochinke, Merel A. W. Oortveld, Hendrik Marks, Daniela Kramer, Eiko K. de Jong, Zoltan Asztalos, J. Timothy Westwood, Hendrik G. Stunnenberg, Marla B. Sokolowski, Krystyna Keleman, Huiqing Zhou, Hans van Bokhoven, Annette Schenck, and Robert R. H. Anholt
PLoS Biology, 2011, Volume 9, Number 1, Page e1000569
[3]
Talal Jamil Qazi, Zhenzhen Quan, Asif Mir, and Hong Qing
Molecular Neurobiology, 2017
[4]
Kyle W. Anderson, Junjun Chen, Meiyao Wang, Natalia Mast, Irina A. Pikuleva, Illarion V. Turko, and Jon M. Jacobs
PLOS ONE, 2015, Volume 10, Number 5, Page e0126592
[5]
Songjun Xu, Priyalakshmi Panikker, Sahira Iqbal, Felice Elefant, and Doris Kretzschmar
PLOS ONE, 2016, Volume 11, Number 7, Page e0159623
[6]
K N Harkess, J Ryan, P H Delfabbro, and S Cohen-Woods
Translational Psychiatry, 2016, Volume 6, Number 11, Page e965
[7]
Maciej Grzybek, Aleksandra Golonko, Marta Walczak, and Pawel Lisowski
Neurobiology of Disease, 2017, Volume 99, Page 84
[8]
Mahima Sharma, Nuralyah Bte Razali, and Sreedharan Sajikumar
Cerebral Cortex, 2016, Page bhw170
[9]
Nicole Gröger, Emmanuel Matas, Tomasz Gos, Alexandra Lesse, Gerd Poeggel, Katharina Braun, and Jörg Bock
Journal of Neural Transmission, 2016, Volume 123, Number 9, Page 1037
[10]
S. Montagud-Romero, J. Montesinos, M. Pascual, M.A. Aguilar, C. Roger-Sanchez, C. Guerri, J. Miñarro, and M. Rodríguez-Arias
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2016, Volume 70, Page 39
[11]
Kyle W. Anderson, Natalia Mast, Irina A. Pikuleva, and Illarion V. Turko
FEBS Open Bio, 2015, Volume 5, Number 1, Page 550
[12]
Joerg Bock, Tamar Wainstock, Katharina Braun, and Menahem Segal
Biological Psychiatry, 2015, Volume 78, Number 5, Page 315
[13]
Elisabetta Gerace, Elisa Landucci, Tania Scartabelli, Flavio Moroni, Alberto Chiarugi, and Domenico E. Pellegrini-Giampietro
Neuropharmacology, 2015, Volume 92, Page 125
[14]
Sanaz Bahari-Javan, Farahnaz Sananbenesi, and Andre Fischer
Frontiers in Neuroscience, 2014, Volume 8
[15]
Lillian Geza Rothenberger, Gerhard W. Lauth, Nicole Ramacher-Faasen, Anna Katharina Braun, Jörg Bock, Sigrid von Aster, Matthias von Aster, and Michael von Aster
Lernen und Lernstörungen, 2014, Volume 3, Number 3, Page 185
[16]
Beatrice Arosio, Claudio D'Addario, Cristina Gussago, Martina Casati, Enzo Tedone, Evelyn Ferri, Paola Nicolini, Paolo D. Rossi, Mauro Maccarrone, and Daniela Mari
BioMed Research International, 2014, Volume 2014, Page 1
[17]
Zhiguo Xie, Christopher Chang, and Zhiguang Zhou
Clinical Reviews in Allergy & Immunology, 2014, Volume 47, Number 2, Page 174
[19]
Jörn Lötsch, Gisbert Schneider, Daniel Reker, Michael J. Parnham, Petra Schneider, Gerd Geisslinger, and Alexandra Doehring
Trends in Molecular Medicine, 2013, Volume 19, Number 12, Page 742
[20]
Vincent B. Owona Ayissi, Azadeh Ebrahimi, and Hermann Schluesenner
Molecular Nutrition & Food Research, 2014, Volume 58, Number 1, Page 22
[21]
R. C. Agis-Balboa and A. Fischer
Cellular and Molecular Life Sciences, 2014, Volume 71, Number 1, Page 21
[22]
M. Razafsha, H. Behforuzi, H. Harati, R.AL. Wafai, A. Khaku, S. Mondello, M.S. Gold, and F.H. Kobeissy
Neuroscience, 2013, Volume 240, Page 204
[23]
[24]
Zhi-Yuan Zhang and Hermann J. Schluesener
Journal of Neuropathology & Experimental Neurology, 2013, Volume 72, Number 3, Page 178
[25]
Alkomiet Hasan, Amanda Mitchell, Anja Schneider, Tobias Halene, and Schahram Akbarian
European Archives of Psychiatry and Clinical Neuroscience, 2013, Volume 263, Number 4, Page 273
[26]
Johannes Gräff and Li-Huei Tsai
Nature Reviews Neuroscience, 2013, Volume 14, Number 2, Page 97
[27]
Nambirajan Govindarajan, Pooja Rao, Susanne Burkhardt, Farahnaz Sananbenesi, Oliver M. Schlüter, Frank Bradke, Jianrong Lu, and André Fischer
EMBO Molecular Medicine, 2013, Volume 5, Number 1, Page 52
[28]
M. Decressac and R.A. Barker
Experimental Neurology, 2012, Volume 238, Number 2, Page 265
[29]
Thomas Buchheit, Thomas Van de Ven, and Andrew Shaw
Pain Medicine, 2012, Volume 13, Number 11, Page 1474
[30]
Kangling Zhang, Matthew Schrag, Andrew Crofton, Rishi Trivedi, Harry Vinters, and Wolff Kirsch
PROTEOMICS, 2012, Volume 12, Number 8, Page 1261
[31]
Alejandra Huerta-Rivas, Carolina López-Rubalcava, Sinthia L. Sánchez-Serrano, Mariana Valdez-Tapia, Mónica Lamas, and Silvia L. Cruz
Pharmacology Biochemistry and Behavior, 2012, Volume 102, Number 1, Page 48
[32]
Jennifer A Rusiecki, Ligong Chen, Vasantha Srikantan, Lei Zhang, Liying Yan, Matthew L Polin, and Andrea Baccarelli
Epigenomics, 2012, Volume 4, Number 1, Page 29
[33]
Anna Kaliszewska and Philip L. De Jager
Journal of Neuroimmunology, 2012, Volume 248, Number 1-2, Page 2
[34]
Alexandra Doehring, Gerd Geisslinger, and Jörn Lötsch
European Journal of Pain, 2011, Volume 15, Number 1, Page 11
[35]
Andrea Schmitt, Alkomiet Hasan, Oliver Gruber, and Peter Falkai
European Archives of Psychiatry and Clinical Neuroscience, 2011, Volume 261, Number S2, Page 150
[36]
Roberto Carlos Agis-Balboa, Dario Arcos-Diaz, Jessica Wittnam, Nambirajan Govindarajan, Kim Blom, Susanne Burkhardt, Ulla Haladyniak, Hope Yao Agbemenyah, Athanasios Zovoilis, Gabriella Salinas-Riester, Lennart Opitz, Farahnaz Sananbenesi, and Andre Fischer
The EMBO Journal, 2011, Volume 30, Number 19, Page 4071
[37]
Roman Manuel Stilling and André Fischer
Neurobiology of Learning and Memory, 2011, Volume 96, Number 1, Page 19
[38]
André Fischer, Farahnaz Sananbenesi, Alison Mungenast, and Li-Huei Tsai
Trends in Pharmacological Sciences, 2010, Volume 31, Number 12, Page 605
[39]
Helmut Sies
Biological Chemistry, 2009, Volume 390, Number 11
[40]
Victor V Levenson
Expert Review of Molecular Diagnostics, 2010, Volume 10, Number 4, Page 481
[41]
Hideharu Hashimoto, Paula M Vertino, and Xiaodong Cheng
Epigenomics, 2010, Volume 2, Number 5, Page 657
[42]
Jeremy J Day and J David Sweatt
Nature Neuroscience, 2010, Volume 13, Number 11, Page 1319
[43]
Andre Fischer
Pharmazie in unserer Zeit, 2010, Volume 39, Number 3, Page 204

Comments (0)

Please log in or register to comment.
Log in