Jump to ContentJump to Main Navigation
Show Summary Details

Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Turk, Boris / Wittinghofer, Alfred

12 Issues per year

IMPACT FACTOR 2015: 2.710
Rank 142 out of 289 in category Biochemistry & Molecular Biology in the 2015 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR) 2015: 1.607
Source Normalized Impact per Paper (SNIP) 2015: 0.751
Impact per Publication (IPP) 2015: 2.609

See all formats and pricing
Just Accepted


The liaison between apoptotic cells and macrophages – the end programs the beginning

Andreas Weigert
  • Institute of Biochemistry I/ZAFES, Faculty of Medicine, Goethe University Frankfurt, D-60590 Frankfurt, Germany
/ Carla Jennewein
  • Institute of Biochemistry I/ZAFES, Faculty of Medicine, Goethe University Frankfurt, D-60590 Frankfurt, Germany
/ Bernhard Brüne
  • Institute of Biochemistry I/ZAFES, Faculty of Medicine, Goethe University Frankfurt, D-60590 Frankfurt, Germany
Published Online: 2009-03-31 | DOI: https://doi.org/10.1515/BC.2009.048


The efficient execution of apoptotic cell death with the clearance of apoptotic debris by phagocytes is a key regulatory mechanism ensuring tissue homeostasis. Failure in this execution program contributes to the pathogenesis of many human diseases. In this review, we describe the current knowledge regarding the interaction of apoptotic cells with their professional ‘captors’, the macrophages, with special emphasis on the immunological outcome. Removal of apoptotic cells must be considered as a process that actively delivers signals to polarize macrophages, which are fundamental for the resolution of inflammation. However, the sculpting of macrophage responses by apoptotic cells can be misused under certain inflammatory disease conditions, including tumor development.

Keywords: apoptosis; NF-κB; phagocytosis; phosphatidylserine; sphingosine-1-phosphate; transforming growth factor β (TGF-β)

About the article

Corresponding author

Received: 2009-01-27

Accepted: 2009-02-25

Published Online: 2009-03-31

Published in Print: 2009-01-01

Citation Information: Biological Chemistry, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2009.048. Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

H Chen, R Shi, B Luo, X Yang, L Qiu, J Xiong, M Jiang, Y Liu, Z Zhang, and Y Wu
Cell Death and Disease, 2015, Volume 6, Number 1, Page e1597
Aja M. Rieger, Jeffrey J. Havixbeck, Miodrag Belosevic, and Daniel R. Barreda
Developmental & Comparative Immunology, 2015, Volume 49, Number 2, Page 259
Tamara P. Kondratyuk, Eun-Jung Park, Rui Yu, Richard B. van Breemen, Ratnakar N. Asolkar, Brian T. Murphy, William Fenical, and John M. Pezzuto
Marine Drugs, 2012, Volume 10, Number 12, Page 451
Jacob H. Swet, Hernando J. Pacheco, David A. Iannitti, Ahmed El-Ghanam, and Iain H. McKillop
Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2014, Volume 102, Number 1, Page 190
Aja M. Rieger, Jeffrey D. Konowalchuk, Jeffrey J. Havixbeck, John S. Robbins, Matthew K. Smith, Johanna M. Lund, and Daniel R. Barreda
Developmental & Comparative Immunology, 2013, Volume 39, Number 4, Page 438
Stephanie Ley, Andreas Weigert, Jean-Karim Hériché, Blandine Mille-Baker, Richard A.J. Janssen, and Bernhard Brüne
Immunobiology, 2013, Volume 218, Number 1, Page 40
Anna Sola, Andreas Weigert, Michaela Jung, Eugenia Vinuesa, Kerstin Brecht, Nicole Weis, Bernhard Brüne, Niels Borregaard, and Georgina Hotter
The Journal of Pathology, 2011, Volume 225, Number 4, Page 597
Nicolas Dumont and Jérôme Frenette
The American Journal of Pathology, 2010, Volume 176, Number 5, Page 2228
Michaela Keuper, Matthias Blüher, Michael R. Schön, Peter Möller, Anna Dzyakanchuk, Kurt Amrein, Klaus-Michael Debatin, Martin Wabitsch, and Pamela Fischer-Posovszky
Molecular and Cellular Endocrinology, 2011, Volume 339, Number 1-2, Page 105
Tim Kees and Mikala Egeblad
Journal of Mammary Gland Biology and Neoplasia, 2011, Volume 16, Number 3, Page 189
Rodger Duffin, Andrew E. Leitch, Sarah Fox, Chris Haslett, and Adriano G. Rossi
Immunological Reviews, 2010, Volume 236, Number 1, Page 28

Comments (0)

Please log in or register to comment.
Log in