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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Turk, Boris / Wittinghofer, Alfred

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IMPACT FACTOR 2015: 2.710
Rank 142 out of 289 in category Biochemistry & Molecular Biology in the 2015 Thomson Reuters Journal Citation Report/Science Edition

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1437-4315
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The liaison between apoptotic cells and macrophages – the end programs the beginning

Andreas Weigert
  • Institute of Biochemistry I/ZAFES, Faculty of Medicine, Goethe University Frankfurt, D-60590 Frankfurt, Germany
/ Carla Jennewein
  • Institute of Biochemistry I/ZAFES, Faculty of Medicine, Goethe University Frankfurt, D-60590 Frankfurt, Germany
/ Bernhard Brüne
  • Institute of Biochemistry I/ZAFES, Faculty of Medicine, Goethe University Frankfurt, D-60590 Frankfurt, Germany
Published Online: 2009-03-31 | DOI: https://doi.org/10.1515/BC.2009.048

Abstract

The efficient execution of apoptotic cell death with the clearance of apoptotic debris by phagocytes is a key regulatory mechanism ensuring tissue homeostasis. Failure in this execution program contributes to the pathogenesis of many human diseases. In this review, we describe the current knowledge regarding the interaction of apoptotic cells with their professional ‘captors’, the macrophages, with special emphasis on the immunological outcome. Removal of apoptotic cells must be considered as a process that actively delivers signals to polarize macrophages, which are fundamental for the resolution of inflammation. However, the sculpting of macrophage responses by apoptotic cells can be misused under certain inflammatory disease conditions, including tumor development.

Keywords: apoptosis; NF-κB; phagocytosis; phosphatidylserine; sphingosine-1-phosphate; transforming growth factor β (TGF-β)

About the article

Corresponding author


Received: 2009-01-27

Accepted: 2009-02-25

Published Online: 2009-03-31

Published in Print: 2009-01-01


Citation Information: Biological Chemistry, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2009.048. Export Citation

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