Jump to ContentJump to Main Navigation
Show Summary Details
Weitere Optionen …

Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Wissenschaftlicher Beirat: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred


IMPACT FACTOR 2018: 3.014
5-year IMPACT FACTOR: 3.162

CiteScore 2018: 3.09

SCImago Journal Rank (SJR) 2018: 1.482
Source Normalized Impact per Paper (SNIP) 2018: 0.820

Online
ISSN
1437-4315
Alle Formate und Preise
Weitere Optionen …
Just Accepted

Hefte

Retrodifferentiation – a mechanism for cellular regeneration?

Ralf Hass
  • Department of Obstetrics and Gynecology, Biochemistry and Tumor Biology Laboratory, Medical University Hannover, D-30625 Hannover, Germany
  • Weitere Artikel des Autors:
  • De Gruyter OnlineGoogle Scholar
Online erschienen: 31.03.2009 | DOI: https://doi.org/10.1515/BC.2009.050

Abstract

Cellular differentiation can be characterized by the acquisition of specified properties during several steps of development whereby the original stem- or precursor-like populations can finally obtain a certain phenotype with highly specific cell functions. The continuing maturation process can be paralleled by progressively reduced proliferative capacity in various cell types functioning as postmitotic tissues. Conversely, other cell populations (e.g., distinct immune cells) may carry out their specific function upon stimulation of proliferation. While these differentiated phenotypes perform their appropriate specific duties throughout the functioning organism, nature may provide an interesting alternative within this concept of life: sometimes, differentiation steps appear to be reversible. Thus, retrograde differentiation – also termed retrodifferentiation – and accordingly rejuvenation may occur when differentiated cells lose their specific properties acquired during previous steps of maturation. Consequently, retrodifferentiation and rejuvenation could provide enormous potential for tissue repair and cell renewal; however, regulatory dysfunctions within these retrograde developments may also involve the risk of tumor promotion.

Keywords: aging; dedifferentiation; life span; longevity; rejuvenation; senescence; transdifferentiation; tumorigenesis

Artikelinformationen


Erhalten: 05.01.2009

Angenommen: 26.02.2009

Online erschienen: 31.03.2009

Erschienen im Druck: 01.01.2009


Quellenangabe: Biological Chemistry, Band 390, Heft 5/6, Seiten 409–416, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2009.050.

Zitat exportieren

Zitierende Artikel

Hier finden Sie eine Übersicht über alle Crossref-gelisteten Publikationen, in denen dieser Artikel zitiert wird. Um automatisch über neue Zitierungen dieses Artikels informiert zu werden, aktivieren Sie einfach oben auf dieser Seite den „E-Mail-Alert: Neu zitiert“.

[1]
Ralf Hass, Juliane von der Ohe, and Hendrik Ungefroren
Cancers, 2019, Jahrgang 11, Nummer 10, Seite 1432
[3]
Seong Wook Hwang, Sun Jae Lee, Po Eun Park, Mee Seon Kim, and Han-Ik Bae
Basic and Applied Pathology, 2012, Jahrgang 5, Nummer 1, Seite 22
[4]
Jennifer Black, Cheryl M. Coffin, and Louis P. Dehner
Pediatric and Developmental Pathology, 2012, Jahrgang 15, Nummer 1_suppl, Seite 181
[5]
Anna Otte, Katharina Mandel, Gesche Reinstrom, and Ralf Hass
Cell Communication and Signaling, 2011, Jahrgang 9, Nummer 1, Seite 20
[6]
Sukhada Chaturvedi and Ralf Hass
Mechanisms of Ageing and Development, 2011, Jahrgang 132, Nummer 5, Seite 213
[7]
Ralf Hass
Experimental Gerontology, 2009, Jahrgang 44, Nummer 10, Seite 634
[8]
Cornelia Kasper, Antonina Lavrentieva, and Ralf Hass
BIOspektrum, 2011, Jahrgang 17, Nummer 4, Seite 422
[9]
Ralf Hass, Cornelia Kasper, Stefanie Böhm, and Roland Jacobs
Cell Communication and Signaling, 2011, Jahrgang 9, Nummer 1, Seite 12

Kommentare (0)