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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred


IMPACT FACTOR 2018: 3.014
5-year IMPACT FACTOR: 3.162

CiteScore 2018: 3.09

SCImago Journal Rank (SJR) 2018: 1.482
Source Normalized Impact per Paper (SNIP) 2018: 0.820

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1431-6730
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Krüppel-like factor 4 represses transcription of the survivin gene in esophageal cancer cell lines

Guo Zhang
  • Laboratory of Cell and Molecular Biology, National Laboratory of Molecular Oncology, Cancer Institute, Chinese Academy of Medical Sciences, Beijing 100021, P.R. China
  • These authors contributed equally to this work.
  • Present address: Department of Physiology, University of Wisconsin-Madison, Madison, WI 53706, USA.
  • Other articles by this author:
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/ Hongxia Zhu
  • Laboratory of Cell and Molecular Biology, National Laboratory of Molecular Oncology, Cancer Institute, Chinese Academy of Medical Sciences, Beijing 100021, P.R. China
  • These authors contributed equally to this work.
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Yihua Wang
  • Laboratory of Cell and Molecular Biology, National Laboratory of Molecular Oncology, Cancer Institute, Chinese Academy of Medical Sciences, Beijing 100021, P.R. China
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Shangbin Yang
  • Laboratory of Cell and Molecular Biology, National Laboratory of Molecular Oncology, Cancer Institute, Chinese Academy of Medical Sciences, Beijing 100021, P.R. China
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  • De Gruyter OnlineGoogle Scholar
/ Mei Liu
  • Laboratory of Cell and Molecular Biology, National Laboratory of Molecular Oncology, Cancer Institute, Chinese Academy of Medical Sciences, Beijing 100021, P.R. China
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  • De Gruyter OnlineGoogle Scholar
/ Wei Zhang
  • Laboratory of Cell and Molecular Biology, National Laboratory of Molecular Oncology, Cancer Institute, Chinese Academy of Medical Sciences, Beijing 100021, P.R. China
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  • De Gruyter OnlineGoogle Scholar
/ Lanping Quan
  • Laboratory of Cell and Molecular Biology, National Laboratory of Molecular Oncology, Cancer Institute, Chinese Academy of Medical Sciences, Beijing 100021, P.R. China
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/ Jinfeng Bai
  • Laboratory of Cell and Molecular Biology, National Laboratory of Molecular Oncology, Cancer Institute, Chinese Academy of Medical Sciences, Beijing 100021, P.R. China
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/ Zhihua Liu
  • Laboratory of Cell and Molecular Biology, National Laboratory of Molecular Oncology, Cancer Institute, Chinese Academy of Medical Sciences, Beijing 100021, P.R. China
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  • De Gruyter OnlineGoogle Scholar
/ Ningzhi Xu
  • Laboratory of Cell and Molecular Biology, National Laboratory of Molecular Oncology, Cancer Institute, Chinese Academy of Medical Sciences, Beijing 100021, P.R. China
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Published Online: 2009-04-10 | DOI: https://doi.org/10.1515/BC.2009.060

Abstract

Aberrant expression of survivin has been shown to be regulated at the transcription level in cancer cells. In this study, we demonstrate that there are six putative binding sites of Krüppel-like factor 4 (KLF4) within the 2000-bp region upstream of the transcription start site of the human survivin gene. Luciferase reporter gene assays revealed that survivin promoter activity is repressed upon overexpression of KLF4 in EC9706 cells. A chromatin immunoprecipitation assay indicated that KLF4 indeed binds the survivin promoter in vivo. It specifically binds the site located at position -40 among the six binding sites as determined by electrophoretic mobility shift assay. Ectopic expression of KLF4 decreases the mRNA and protein levels of survivin. Furthermore, overexpression of survivin partially reverses KLF4-induced cell apoptosis. These results indicate that KLF4 is a transcriptional repressor of the human survivin gene in esophageal squamous cancer cells.

Keywords: Krüppel-like factor 4; survivin; transcription repression

About the article

Corresponding author


Received: 2008-11-11

Accepted: 2009-03-17

Published Online: 2009-04-10

Published in Print: 2009-01-01


Citation Information: Biological Chemistry, Volume 390, Issue 5/6, Pages 463–469, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2009.060.

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