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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred


IMPACT FACTOR 2018: 3.014
5-year IMPACT FACTOR: 3.162

CiteScore 2018: 3.09

SCImago Journal Rank (SJR) 2018: 1.482
Source Normalized Impact per Paper (SNIP) 2018: 0.820

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1437-4315
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Identification and characterization of a bioactive lantibiotic produced by Staphylococcus warneri

Jørgen Petersen
  • ACE BioSciences A/S, Unsbjergvej 2a, DK-5220 Odense, Denmark
  • Present address: Danish Technological Institute, Holbergsvej 10, DK-6000 Kolding, Denmark.
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Anders Boysen / Lotte Fogh / Kathrine Tabermann / Thomas Kofoed / Angus King / Petra Schrotz-King / Martin Christian Hansen
Published Online: 2009-04-10 | DOI: https://doi.org/10.1515/BC.2009.062

Abstract

Lantibiotics are a group of potent antibacterial agents that contain unusual amino acids, such as the thioether amino acids lanthionine and methyllanthionine, and the didehydroamino acids didehydroalanine and didehydro-aminobutyric acid. Here, we report on an antibacterial lantibiotic peptide named SWLP1 (Staphylococcus warneri lantibiotic peptide 1), which is secreted from Staphylococcus warneri (deposited with DSMZ, accession number DSM 16081). SWLP1 was purified from growth media. The purified peptide displays antibacterial activity against several species, including Staphylococcus epidermidis. The molecular mass of SWLP1 is 2998.9 Da as determined by matrix-assisted laser desorption ionization time-of-flight mass spectrometry. The sequence and possible structure was elucidated by combining electrospray ionization mass spectrometry/mass spectrometry data of ethanethiol-treated and non-ethanethiol-treated tryptic fragments of the SWLP1. SWLP1 contains three thioether bridges, one didehydroalanine, and three didehydroaminobutyric acids. This peptide has the potential to be used in treatment of several Gram-positive bacterial infections.

Keywords: electrospray ionization mass spectrometry (ESI-MS); lantibiotic; matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS); Staphylococcus warneri

About the article

Corresponding author


Received: 2009-01-13

Accepted: 2009-03-18

Published Online: 2009-04-10

Published in Print: 2009-01-01


Citation Information: Biological Chemistry, Volume 390, Issue 5/6, Pages 437–444, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2009.062.

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