Jump to ContentJump to Main Navigation
Show Summary Details

Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Turk, Boris / Wittinghofer, Alfred

SCImago Journal Rank (SJR) 2015: 1.607
Source Normalized Impact per Paper (SNIP) 2015: 0.751
Impact per Publication (IPP) 2015: 2.609

249,00 € / $374.00 / £187.00*

See all formats and pricing



Select Volume and Issue


Management of the human mucosal defensive barrier: evidence for glycan legislation

Georgios Patsos1, a / Anthony Corfield1

1Department of Clinical Science at South Bristol, University of Bristol, Bristol BS2 8HW, UK

aPresent address: Institut für Pathologie, Universitätsklinik Heidelberg, D-69120 Heidelberg, Germany.

Corresponding author

Citation Information: Biological Chemistry. Volume 390, Issue 7, Pages 581–590, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: 10.1515/BC.2009.052, March 2009

Publication History

Published Online:


The human gastrointestinal barrier comprises several layers which enable protection against the external environment. The mucosal epithelium, lamina propria, glycocalyx and secreted mucus each make a contribution to barrier protection. Glycocalyx and secreted mucins constitute a glycosylated environment which interacts with the enteric microflora. Turnover of the mucus layer and the creation of binding ligands for bacteria are significant factors in gut homeostasis. The gut microbiota is composed of many bacterial species, but improved technology has allowed detection of populations present at different stages of development and in disease. Interaction of the microflora with the gut occurs from birth onwards and enables maturation of gut angiogenesis and glycosylation as demonstrated in mouse models. Glycan legislation regulates the ongoing interaction between the microflora and the host mucosa. This accounts for host glycosylation mechanisms providing a dynamic response to fluctuations in the gut microflora. Evidence for glycan legislation is based on a surgical model where intact mucosa can be compared with and without contact to the faecal microflora. In addition, mucosal cell glycosylation is assessed using inhibitors of O-glycan synthesis. These inhibitors lead to growth arrest in cultured colorectal cancer cell lines through the induction of apoptosis and downregulation of proliferation.

Keywords: gastrointestinal; glycan; glycocalyx; inhibitors; microflora; mucin

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Valérie Gouyer, Laurent Dubuquoy, Catherine Robbe-Masselot, Christel Neut, Elisabeth Singer, Ségolène Plet, Karel Geboes, Pierre Desreumaux, Frédéric Gottrand, and Jean-Luc Desseyn
Scientific Reports, 2015, Volume 5, Page 9577
Keita Nishiyama, Akira Kawanabe, Hirofumi Miyauchi, Fumiaki Abe, Daigo Tsubokawa, Kazuhiko Ishihara, Yuji Yamamoto, and Takao Mukai
Bioscience, Biotechnology, and Biochemistry, 2014, Volume 78, Number 8, Page 1444
Anthony P. Corfield
Biochimica et Biophysica Acta (BBA) - General Subjects, 2015, Volume 1850, Number 1, Page 236
Maxwell L. Van Tassell and Michael J. Miller
Nutrients, 2011, Volume 3, Number 12, Page 613
A. A. Pedroso, J. Maurer, Y. Cheng, and M. D. Lee
The Journal of Applied Poultry Research, 2012, Volume 21, Number 2, Page 432
A. Marcobal, A. M. Southwick, K. A. Earle, and J. L. Sonnenburg
Glycobiology, 2013, Volume 23, Number 9, Page 1038
Stephen E. Harding
Biotechnology and Genetic Engineering Reviews, 2012, Volume 28, Number 1, Page 177
Sanna Meriläinen, Jyrki Mäkelä, Raija Sormunen, Hanna Alaoja Jensen, Riikka Rimpiläinen, Merja Vakkala, Jussi Rimpiläinen, Pasi Ohtonen, Juha Koskenkari, Vesa Koivukangas, Tuomo Karttunen, Petri Lehenkari, Ilmo Hassinen, and Tatu Juvonen
Ultrastructural Pathology, 2013, Volume 37, Number 2, Page 127
María Ángeles Esteban
ISRN Immunology, 2012, Volume 2012, Page 1
Simon Hohenester, Lucas Maillette de Buy Wenniger, Coen C. Paulusma, Sandra J. van Vliet, Douglas M. Jefferson, Ronald P. Oude Elferink, and Ulrich Beuers
Hepatology, 2012, Volume 55, Number 1, Page 173
Samah M. A. Issa, Benjamin L. Schulz, Nicolle H. Packer, and Niclas G. Karlsson
ELECTROPHORESIS, 2011, Volume 32, Number 24, Page 3554
Maria van der Marel, Mikołaj Adamek, Santiago F. Gonzalez, Patrick Frost, Jan H.W.M. Rombout, Geert F. Wiegertjes, Huub F.J. Savelkoul, and Dieter Steinhagen
Fish & Shellfish Immunology, 2012, Volume 32, Number 3, Page 494
Adam Macierzanka, Neil M. Rigby, Anthony P. Corfield, Nikolaus Wellner, Franziska Böttger, E. N. Clare Mills, and Alan R. Mackie
Soft Matter, 2011, Volume 7, Number 18, Page 8077
Avrelija Cencič and Tomaž Langerholc
International Journal of Food Microbiology, 2010, Volume 141, Page S4
Biological Chemistry, 2009, Volume 390, Number 7
Brian M. Schuster, Lauren A. Perry, Vaughn S. Cooper, and Cheryl A. Whistler
Symbiosis, 2010, Volume 51, Number 1, Page 85

Comments (0)

Please log in or register to comment.