Jump to ContentJump to Main Navigation
Show Summary Details

Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Turk, Boris / Wittinghofer, Alfred

SCImago Journal Rank (SJR) 2015: 1.607
Source Normalized Impact per Paper (SNIP) 2015: 0.751
Impact per Publication (IPP) 2015: 2.609

249,00 € / $374.00 / £187.00*

See all formats and pricing



Select Volume and Issue


Regulative interactions of the osmosensing C-terminal domain in the trimeric glycine betaine transporter BetP from Corynebacterium glutamicum

Reinhard Krämer1 / Christine Ziegler2

1Institute of Biochemistry, University of Cologne, D-50674 Cologne, Germany

2Department of Structural Biology, Max Planck Institute of Biophysics, D-60438 Frankfurt/Main, Germany

Corresponding author

Citation Information: Biological Chemistry. Volume 390, Issue 8, Pages 685–691, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: 10.1515/BC.2009.068, May 2009

Publication History

Published Online:


Activation of the osmoregulated trimeric betaine transporter BetP from Corynebacterium glutamicum was shown to depend mainly on the correct folding and integrity of its 55 amino acid long, partly α-helical C-terminal domain. Reorientation of the three C-terminal domains in the BetP trimer indicates different lipid-protein and protein-protein interactions of the C-terminal domain during osmoregulation. A regulation mechanism is suggested where this domain switches the transporter from the inactive to the active state. Interpretation of recently obtained electron and X-ray crystallography data of BetP led to a structure-function based model of C-terminal molecular switching involved in osmoregulation.

Keywords: anionic lipids; glycine betaine; lipid-protein interaction; molecular switch; osmotic stress regulation; structure; transport; trimer

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Kunal R. Pandit and Jeffery B. Klauda
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2012, Volume 1818, Number 5, Page 1205
L. Ge, C. Perez, I. Waclawska, C. Ziegler, and D. J. Muller
Proceedings of the National Academy of Sciences, 2011, Volume 108, Number 43, Page E890
Ching-Ju Tsai and Christine Ziegler
Current Opinion in Structural Biology, 2010, Volume 20, Number 4, Page 448
Camilo Perez, Caroline Koshy, Susanne Ressl, Sascha Nicklisch, Reinhard Krämer, and Christine Ziegler
The EMBO Journal, 2011, Volume 30, Number 7, Page 1221

Comments (0)

Please log in or register to comment.