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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred

12 Issues per year

IMPACT FACTOR 2016: 3.273

CiteScore 2016: 3.01

SCImago Journal Rank (SJR) 2016: 1.679
Source Normalized Impact per Paper (SNIP) 2016: 0.800

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Volume 390, Issue 8


ZMPSTE24, an integral membrane zinc metalloprotease with a connection to progeroid disorders

Jemima Barrowman
  • Department of Cell Biology, The Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Baltimore, MD 21205, USA
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Susan Michaelis
  • Department of Cell Biology, The Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Baltimore, MD 21205, USA
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2009-05-20 | DOI: https://doi.org/10.1515/BC.2009.080


ZMPSTE24 is an integral membrane zinc metalloprotease originally discovered in yeast as an enzyme (called Ste24p) required for maturation of the mating pheromone a-factor. Surprisingly, ZMPSTE24 has recently emerged as a key protease involved in human progeroid disorders. ZMPSTE24 has only one identified mammalian substrate, the precursor of the nuclear scaffold protein lamin A. ZMPSTE24 performs a critical endoproteolytic cleavage step that removes the hydrophobic farnesyl-modified tail of prelamin A. Failure to do so has drastic consequences for human health and longevity. Here, we discuss the discovery of the yeast and mammalian ZMPSTE24 orthologs and review the unexpected connection between ZMPSTE24 and premature aging.

Keywords: a-factor; Hutchinson-Gilford Progeria Syndrome (HGPS); mandibuloacral dysplasia (MAD); prelamin A; restrictive dermopathy (RD); Ste24

About the article

Corresponding author

Received: 2009-02-19

Accepted: 2009-04-15

Published Online: 2009-05-20

Published in Print: 2009-08-01

Citation Information: Biological Chemistry, Volume 390, Issue 8, Pages 761–773, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2009.080.

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