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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred

IMPACT FACTOR 2018: 3.014
5-year IMPACT FACTOR: 3.162

CiteScore 2018: 3.09

SCImago Journal Rank (SJR) 2018: 1.482
Source Normalized Impact per Paper (SNIP) 2018: 0.820

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Volume 390, Issue 8


Mitochondrial tRNA import – the challenge to understand has just begun

Juan D. Alfonzo
  • Department of Microbiology, Ohio State University Biochemistry Program and The Center for RNA Biology, The Ohio State University, Columbus, OH 43210-1292, USA
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Dieter Söll
  • Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA
  • Department of Chemistry, Yale University, New Haven, CT 06520, USA
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2009-06-27 | DOI: https://doi.org/10.1515/BC.2009.101


Mitochondrial translation is important for the synthesis of proteins involved in oxidative phosphorylation, which yields the bulk of the ATP made in cells. During evolution most mitochondria-containing organisms have lost tRNA genes from their mitochondrial genomes. Thus, to support the essential process of nuanced mitochondrial translation, mechanisms to actively transport tRNAs from the cytoplasm across the mitochondrial membranes into the mitochondrion have evolved. Here, we review the currently known tRNA import mechanisms, comment on recent discoveries of various import factors, and suggest a rationale for forces that lie behind the evolution of mitochondrial tRNA import.

Keywords: import; localization; mitochondria; protein complex; tRNA

About the article

Corresponding authors ;

Received: 2009-02-23

Accepted: 2009-05-11

Published Online: 2009-06-27

Published in Print: 2009-08-01

Citation Information: Biological Chemistry, Volume 390, Issue 8, Pages 717–722, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2009.101.

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