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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred

12 Issues per year


IMPACT FACTOR 2017: 3.022

CiteScore 2017: 2.81

SCImago Journal Rank (SJR) 2017: 1.562
Source Normalized Impact per Paper (SNIP) 2017: 0.705

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1437-4315
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Volume 390, Issue 8

Issues

Protein transport across the peroxisomal membrane

Wolfgang Girzalsky
  • Abteilung für Systembiochemie, Medizinische Fakultät der Ruhr-Universität Bochum, D-44780 Bochum, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Harald W. Platta
  • Abteilung für Systembiochemie, Medizinische Fakultät der Ruhr-Universität Bochum, D-44780 Bochum, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Ralf Erdmann
  • Abteilung für Systembiochemie, Medizinische Fakultät der Ruhr-Universität Bochum, D-44780 Bochum, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2009-06-27 | DOI: https://doi.org/10.1515/BC.2009.104

Abstract

The maintenance of peroxisome function depends on the formation of the peroxisomal membrane and the subsequent import of both membrane and matrix proteins. Without exception, peroxisomal matrix proteins are nuclear encoded, synthesized on free ribosomes and subsequently imported post-translationally. In contrast to other translocation systems that transport unfolded polypeptide chains, the peroxisomal import apparatus can facilitate the transport of folded and oligomeric proteins across the peroxisomal membrane. The peroxisomal protein import is mediated by cycling receptors that shuttle between the cytosol and peroxisomal lumen and depends on ATP and ubiquitin. In this brief review, we will summarize our current knowledge on the import of soluble proteins into the peroxisomal matrix.

Keywords: peroxin; peroxisome biogenesis; protein targeting; PTS-receptor; receptor cycle; ubiquitination

About the article

Corresponding author


Received: 2009-02-09

Accepted: 2009-05-12

Published Online: 2009-06-27

Published in Print: 2009-08-01


Citation Information: Biological Chemistry, Volume 390, Issue 8, Pages 745–751, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2009.104.

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