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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred


IMPACT FACTOR 2018: 3.014
5-year IMPACT FACTOR: 3.162

CiteScore 2018: 3.09

SCImago Journal Rank (SJR) 2018: 1.482
Source Normalized Impact per Paper (SNIP) 2018: 0.820

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1437-4315
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Volume 390, Issue 9

Issues

Advanced glycation end product accumulation in rho0 cells without a functional respiratory chain

Norbert Nass
  • Department of Cardiovascular Surgery, Martin Luther University Halle-Wittenberg, Ernst-Grube-Str. 40, D-06120 Halle/Saale, Germany
  • Other articles by this author:
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/ Alexandra Kukat
  • University of Leipzig, Faculty of Medicine, Molecular Cell Therapy, Centre for Biotechnology and Biomedicine, Deutscher Platz 5, D-04103 Leipzig, Germany
  • Karolinska Institutet, Department of Laboratory Medicine, Division of Metabolic Diseases, Novum, S-141 86 Stockholm, Sweden
  • Other articles by this author:
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/ Peter Seibel
  • University of Leipzig, Faculty of Medicine, Molecular Cell Therapy, Centre for Biotechnology and Biomedicine, Deutscher Platz 5, D-04103 Leipzig, Germany
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/ Hans-Jürgen Brömme
  • Institute of Pathophysiology, Martin Luther University of Halle-Wittenberg, Ernst-Grube-Strasse 40, D-06120 Halle/Saale, Germany
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/ Reinhard Schinzel / Rolf-Edgar Silber
  • Department of Cardiovascular Surgery, Martin Luther University Halle-Wittenberg, Ernst-Grube-Str. 40, D-06120 Halle/Saale, Germany
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/ Andreas Simm
  • Department of Cardiovascular Surgery, Martin Luther University Halle-Wittenberg, Ernst-Grube-Str. 40, D-06120 Halle/Saale, Germany
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Published Online: 2009-05-20 | DOI: https://doi.org/10.1515/BC.2009.083

Abstract

Advanced glycation end products (AGEs) accumulate during ageing with reactive oxygen species from the mitochondrial respiratory chain discussed as a driving force. To determine the role of mitochondrial activity for AGE formation, a rho0 derivative of the 143B.TK- osteosarcoma cell line lacking the respiratory chain, was analysed. These cells exhibit decreased superoxide formation but unchanged mitochondrial SOD expression as well as unchanged antioxidative free sulfhydryl (SH) levels. Whereas total protein content shows no differences in AGE levels, cell fractionation and Western blotting demonstrates some changes in the AGE pattern. Thus, the absence of functional respiration has only a negligible impact on AGE accumulation.

Keywords: advanced glycation end products; mitochondria; reactive oxygen species

About the article

Corresponding author


Received: 2009-04-11

Accepted: 2009-04-21

Published Online: 2009-05-20

Published in Print: 2009-09-01


Citation Information: Biological Chemistry, Volume 390, Issue 9, Pages 915–919, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2009.083.

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Biochemistry Insights, 2016, Volume 9, Page BCI.S36141
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Norbert Nass, Hans-Jürgen Brömme, Roland Hartig, Sevil Korkmaz, Saadettin Sel, Frank Hirche, Aoife Ward, Andreas Simm, Stefan Wiemann, Anne E. Lykkesfeldt, Albert Roessner, Thomas Kalinski, and Toshi Shioda
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PLoS ONE, 2014, Volume 9, Number 4, Page e94257
[5]
B. Leuner, M. Max, K. Thamm, C. Kausler, Y. Yakobus, A. Bierhaus, S. Sel, B. Hofmann, R.-E. Silber, A. Simm, and N. Nass
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Stefanie Ruhs, Norbert Nass, Babett Bartling, Hans-Jürgen Brömme, Beatrice Leuner, Veronika Somoza, Ulrich Friess, Rolf-Edgar Silber, and Andreas Simm
Experimental Gerontology, 2010, Volume 45, Number 10, Page 752

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