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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred

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Volume 390, Issue 9 (Sep 2009)


Induced human pluripotent stem cells: promises and open questions

Alexandra Rolletschek
  • Institute for Biological Interfaces (IBG-1), Research Centre Karlsruhe GmbH, Hermann-von-Helmholtz-Platz 1, D-76344 Eggenstein-Leopoldshafen, Germany
/ Anna M. Wobus
  • Leibniz Institute of Plant Genetics and Crop Plant Research (IPK) Gatersleben, Corrensstr. 3, D-06466 Gatersleben, Germany
Published Online: 2009-06-27 | DOI: https://doi.org/10.1515/BC.2009.103


Adult cells have been reprogrammed into induced pluripotent stem (iPS) cells by introducing pluripotency-associated transcription factors. Here, we discuss recent advances and challenges of in vitro reprogramming and future prospects of iPS cells for their use in diagnosis and cell therapy. The generation of patient-specific iPS cells for clinical application requires alternative strategies, because genome-integrating viral vectors may cause insertional mutagenesis. Moreover, when suitable iPS cell lines will be available, efficient and selective differentiation protocols are needed to generate transplantable grafts. Finally, we point to the requirement of a regulatory framework necessary for the commercial use of iPS cells.

Keywords: cell therapy; differentiation; induced pluripotency; in vitro reprogramming; tumour formation

About the article

Corresponding author

Received: 2009-04-06

Accepted: 2009-05-12

Published Online: 2009-06-27

Published in Print: 2009-09-01

Citation Information: Biological Chemistry, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2009.103. Export Citation

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