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Buchner, Johannes

Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Turk, Boris / Wittinghofer, Alfred

SCImago Journal Rank (SJR) 2015: 1.607
Source Normalized Impact per Paper (SNIP) 2015: 0.751
Impact per Publication (IPP) 2015: 2.609

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The hypoxia-inducible factor HIF-1 functions as both a positive and negative modulator of aging

Scott F. Leiser1 / Matt Kaeberlein1, 2

1Department of Pathology, University of Washington, Seattle, WA 98195, USA

2Institute of Aging Research, Guangdong Medical College, Dongguan 523808, China

Corresponding author

Citation Information: Biological Chemistry. Volume 391, Issue 10, Pages 1131–1137, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/bc.2010.123, August 2010

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In the past year and a half, five studies have independently established a direct connection between the hypoxic response transcription factor, HIF-1, and aging in Caenorhabditis elegans. These studies demonstrated that HIF-1 can both promote and limit longevity via pathways that are mechanistically distinct. Here, we review the current state of knowledge regarding modulation of aging by HIF-1 and speculate on potential aspects of HIF-1 function that could be relevant for mammalian longevity and healthspan.

Keywords: Caenorhabditis elegans; dietary restriction; hypoxic response; longevity; stress response

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