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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Turk, Boris / Wittinghofer, Alfred

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Volume 391, Issue 12 (Dec 2010)


Physiology and pathophysiology of the RANKL/RANK system

Reiko Hanada
  • Institute of Molecular Biotechnology (IMBA) of the Austrian Academy of Sciences, A-1030 Vienna, Austria
/ Toshikatsu Hanada
  • Institute of Molecular Biotechnology (IMBA) of the Austrian Academy of Sciences, A-1030 Vienna, Austria
/ Josef M. Penninger
  • Institute of Molecular Biotechnology (IMBA) of the Austrian Academy of Sciences, A-1030 Vienna, Austria
Published Online: 2010-11-18 | DOI: https://doi.org/10.1515/bc.2010.149


The TNF family molecule RANKL and its receptor RANK are key regulators of bone remodeling, lymph node formation, and mammary gland development during pregnancy. RANKL and RANK are also expressed in the central nervous systems (CNS). However, the functional relevance of RANKL/RANK in the brain was entirely unknown. Recently, our group reported that the RANKL/RANK signaling pathway has an essential role in the central regulation of body temperature via the prostaglandin axis. This review discusses novel aspects of the RANKL/RANK system as key regulators of fever and female basal body temperature in the CNS.

Keywords: bone physiology; central nervous systems; fever; immunology; osteoporosis

About the article

Corresponding author

Received: 2010-07-21

Accepted: 2010-09-26

Published Online: 2010-11-18

Published in Print: 2010-12-01

Citation Information: Biological Chemistry, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/bc.2010.149. Export Citation

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