Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred

12 Issues per year


IMPACT FACTOR 2016: 3.273

CiteScore 2016: 3.01

SCImago Journal Rank (SJR) 2016: 1.679
Source Normalized Impact per Paper (SNIP) 2016: 0.800

Online
ISSN
1437-4315
See all formats and pricing
More options …
Volume 391, Issue 5 (May 2010)

Issues

Zinc supplement greatly improves the condition of parkin mutant Drosophila

Nidhi Saini
  • Institute of Molecular Life Sciences, University of Zürich, Winterthurerstrasse 190, CH-8051 Zürich, Switzerland
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Walter Schaffner
  • Institute of Molecular Life Sciences, University of Zürich, Winterthurerstrasse 190, CH-8051 Zürich, Switzerland
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2010-03-20 | DOI: https://doi.org/10.1515/bc.2010.052

Abstract

Parkinson's disease (PD) is a progressive neurodegenerative disorder in which oxidative stress is implicated as a major causative factor. Mutations in the gene encoding Parkin, a ubiquitin ligase, are responsible for a familial form of PD. In a Drosophila disease model lacking Parkin (park25 null mutant), we tested the effect of zinc supplementation. Zinc is an essential trace metal and a component of many enzymes and transcriptional regulators. Unlike copper and iron, zinc is not redox-active and under most conditions serves as an antioxidant. We find that the condition of parkin mutants raised on zinc-supplemented food is greatly improved. At zinc concentrations where controls begin to show adverse effects as a result of the metal supplement, parkin mutants perform best, as manifested in a higher frequency of reaching adulthood, extended lifespan and improved motoric abilities.

Keywords: antioxidant; metal homeostasis; metallothioneins; MTF-1; Parkinson's disease; zinc transporters

About the article

Corresponding author


Received: 2010-01-15

Accepted: 2010-01-26

Published Online: 2010-03-20

Published in Print: 2010-05-01


Citation Information: Biological Chemistry, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/bc.2010.052.

Export Citation

©2010 by Walter de Gruyter Berlin New York. Copyright Clearance Center

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Pablo Calap-Quintana, Javier González-Fernández, Noelia Sebastiá-Ortega, José Llorens, and María Moltó
International Journal of Molecular Sciences, 2017, Volume 18, Number 7, Page 1456
[2]
Ke Du, Ming-Yan Liu, Xin Zhong, and Min-Jie Wei
Scientific Reports, 2017, Volume 7, Number 1
[3]
Patrick C. McHugh, Josephine A. Wright, David R. Brown, and Harm Kampinga
PLoS ONE, 2011, Volume 6, Number 2, Page e17354
[4]
Hai-Wen Zhao, Jie Lin, Xue-Bao Wang, Xing Cheng, Jian-Yong Wang, Bei-Lei Hu, Yan Zhang, Xiong Zhang, Jian-Hong Zhu, and David I Finkelstein
PLoS ONE, 2013, Volume 8, Number 12, Page e83060
[5]
Jana Elena Kessels, Inga Wessels, Hajo Haase, Lothar Rink, and Peter Uciechowski
Journal of Trace Elements in Medicine and Biology, 2016, Volume 37, Page 125
[6]
E. V. Stelmashook, N. K. Isaev, E. E. Genrikhs, G. A. Amelkina, L. G. Khaspekov, V. G. Skrebitsky, and S. N. Illarioshkin
Biochemistry (Moscow), 2014, Volume 79, Number 5, Page 391
[7]
Negar Afshar, Bilge Argunhan, Lucia Bettedi, Joanna Szular, and Fanis Missirlis
FEBS Open Bio, 2013, Volume 3, Number 1, Page 302
[8]
Samantha Hindle, Farinaz Afsari, Meg Stark, C. Adam Middleton, Gareth J.O. Evans, Sean T. Sweeney, and Christopher J.H. Elliott
Human Molecular Genetics, 2013, Volume 22, Number 11, Page 2129
[9]
A. Vincent, L. Briggs, G. F. J. Chatwin, E. Emery, R. Tomlins, M. Oswald, C. A. Middleton, G. J. O. Evans, S. T. Sweeney, and C. J. H. Elliott
Human Molecular Genetics, 2012, Volume 21, Number 8, Page 1760
[10]
Lucia Gutiérrez, Narmatha Sabaratnam, Rubina Aktar, Lucia Bettedi, Konstantinos Mandilaras, and Fanis Missirlis
FEBS Letters, 2010, Volume 584, Number 13, Page 2942
[11]
Haiqing Hua, Lisa Münter, Anja Harmeier, Oleg Georgiev, Gerd Multhaup, and Walter Schaffner
Biological Chemistry, 2011, Volume 392, Number 10
[12]
Verónica Muñoz-Soriano and Nuria Paricio
Parkinson's Disease, 2011, Volume 2011, Page 1
[13]
Nidhi Saini, Sandra Oelhafen, Haiqing Hua, Oleg Georgiev, Walter Schaffner, and Hansruedi Büeler
Neurobiology of Disease, 2010, Volume 40, Number 1, Page 82
[14]
William R. Swindell
Ageing Research Reviews, 2011, Volume 10, Number 1, Page 132

Comments (0)

Please log in or register to comment.
Log in