Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred

12 Issues per year


IMPACT FACTOR 2016: 3.273

CiteScore 2016: 3.01

SCImago Journal Rank (SJR) 2016: 1.679
Source Normalized Impact per Paper (SNIP) 2016: 0.800

Online
ISSN
1437-4315
See all formats and pricing
More options …
Volume 391, Issue 6 (Jun 2010)

Issues

Actin-mediated gene expression in neurons: the MRTF-SRF connection

Bernd Knöll
  • Interfaculty Institute for Cell Biology, Department of Molecular Biology, Neuronal Gene Expression Laboratory, Eberhard-Karls-University Tübingen, Auf der Morgenstelle 15, D-72076 Tübingen, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2010-04-06 | DOI: https://doi.org/10.1515/bc.2010.061

Abstract

The traditional view of cellular actin is a rather autarkic cytoskeletal framework function confined to the cytoplasm. However, there is now evidence that alterations in actin dynamics are sensed by the nucleus and subsequently modulate gene expression. In communicating with the nucleus, cytoplasmic, and most likely also nucleus-resident actin, provides a further (gene) regulatory loop to cell motility. A transcription module composed of MRTF (myocardin-related transcription factor) and SRF (serum response factor) emerges as prime target of such actin signaling. Here, I focus on the nervous system, where the actin-MRTF-SRF entity governs multiple aspects of neuronal motility.

Keywords: axon guidance; cytoskeleton; growth cone; neurite; nucleus; transcription

About the article


Received: 2009-11-27

Accepted: 2010-01-25

Published Online: 2010-04-06

Published in Print: 2010-06-01


Citation Information: Biological Chemistry, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/bc.2010.061.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Zaneta Odrowaz, Andrew D. Sharrocks, and Dominique Leprince
PLoS Genetics, 2012, Volume 8, Number 5, Page e1002694
[2]
Young J. Yoon, Bin Wu, Adina R. Buxbaum, Sulagna Das, Albert Tsai, Brian P. English, Jonathan B. Grimm, Luke D. Lavis, and Robert H. Singer
Proceedings of the National Academy of Sciences, 2016, Volume 113, Number 44, Page E6877
[3]
Shota Yamazaki, Koji Yamamoto, Primal de Lanerolle, and Masahiko Harata
Histochemistry and Cell Biology, 2016, Volume 145, Number 4, Page 389
[4]
James J. Bradstreet, Marco Ruggiero, and Stefania Pacini
Frontiers in Neuroscience, 2015, Volume 9
[5]
Marilyn Scandaglia, Eva Benito, Cruz Morenilla-Palao, Anna Fiorenza, Beatriz del Blanco, Yaiza Coca, Eloísa Herrera, and Angel Barco
Scientific Reports, 2015, Volume 5, Number 1
[6]
Eva Benito and Angel Barco
Molecular Neurobiology, 2015, Volume 51, Number 3, Page 1071
[7]
Mark R. Lundquist, Andrew J. Storaska, Ting-Chun Liu, Scott D. Larsen, Todd Evans, Richard R. Neubig, and Samie R. Jaffrey
Cell, 2014, Volume 156, Number 3, Page 563
[8]
Kevin C Flynn
BioArchitecture, 2013, Volume 3, Number 4, Page 86
[9]
Julia Thran, Burkhard Poeck, and Roland Strauss
Current Biology, 2013, Volume 23, Number 18, Page 1756
[10]
E.I. Ramos, G.A. Bien-Willner, J. Li, A.E.O. Hughes, J. Giacalone, S. Chasnoff, S. Kulkarni, M. Parmacek, F.S. Cole, and T.E. Druley
Clinical Genetics, 2014, Volume 85, Number 5, Page 423
[11]
S Muehlich, V Hampl, S Khalid, S Singer, N Frank, K Breuhahn, T Gudermann, and R Prywes
Oncogene, 2012, Volume 31, Number 35, Page 3913
[12]
Gerald Thiel
Biological Chemistry, 2010, Volume 391, Number 6

Comments (0)

Please log in or register to comment.
Log in