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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred

12 Issues per year

IMPACT FACTOR 2017: 3.022

CiteScore 2017: 2.81

SCImago Journal Rank (SJR) 2017: 1.562
Source Normalized Impact per Paper (SNIP) 2017: 0.705

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Volume 391, Issue 6


RIM proteins and their role in synapse function

Tobias Mittelstaedt / Elena Alvaréz-Baron / Susanne Schoch
  • Department of Epileptology, University of Bonn, D-53105 Bonn, Germany
  • Department of Neuropathology, University of Bonn, D-53105 Bonn, Germany
  • Other articles by this author:
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Published Online: 2010-04-06 | DOI: https://doi.org/10.1515/bc.2010.064


Active zones are specialized areas of the plasma membrane in the presynaptic nerve terminal that mediate neurotransmitter release and synaptic plasticity. The multidomain proteins RIM1 and RIM2 are integral components of the cytomatrix at the active zone, interacting with most other active zone-enriched proteins as well as synaptic vesicle proteins. In the brain, RIMs are present in multiple isoforms (α, β, γ) diverging in their structural composition, which mediate overlapping and distinct functions. Here, we summarize recent findings about the specific roles of the various RIM isoforms in basic synaptic vesicle release as well as long- and short-term presynaptic plasticity.

Keywords: active zone; long-term potentiation (LTP); plasticity; presynaptic; priming; synaptic vesicle

About the article

Corresponding author

Received: 2009-12-23

Accepted: 2010-02-16

Published Online: 2010-04-06

Published in Print: 2010-06-01

Citation Information: Biological Chemistry, Volume 391, Issue 6, Pages 599–606, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/bc.2010.064.

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