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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred

12 Issues per year

IMPACT FACTOR 2016: 3.273

CiteScore 2016: 3.01

SCImago Journal Rank (SJR) 2016: 1.679
Source Normalized Impact per Paper (SNIP) 2016: 0.800

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Volume 391, Issue 7 (Jul 2010)


Towards molecular systems biology of gene transcription and regulation

Patrick Cramer
  • Gene Center and Department of Biochemistry, Center for Integrated Protein Science CIPSM, Ludwig Maximilians University, Feodor-Lynen-Straße 25, D-81377 Munich, Germany
Published Online: 2010-05-19 | DOI: https://doi.org/10.1515/bc.2010.094


Ten years after the determination of the RNA polymerase II structure, the basic mechanism of mRNA synthesis during gene transcription is known. In the future, the initiation and regulation of transcription must be studied with a combination of structural biology, biochemistry, functional genomics, and computational methods. In this article, the efforts of our laboratory to move from an integrated structural biology of gene transcription towards molecular systems biology of gene regulation are reviewed.

Keywords: gene transcription and regulation; integrated structural biology; molecular systems biology; RNA polymerase; yeast

About the article

Received: 2010-01-26

Accepted: 2010-03-31

Published Online: 2010-05-19

Published in Print: 2010-07-01

Citation Information: Biological Chemistry, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/bc.2010.094.

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