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Thomas, Douglas D.

Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Turk, Boris / Wittinghofer, Alfred

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1437-4315
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In This Section
Volume 392, Issue 1-2 (Feb 2011)

Issues

The lysosomal polypeptide transporter TAPL: more than a housekeeping factor?

Irina Bangert
  • Institute of Biochemistry, Biocenter, Goethe University Frankfurt, Max-von-Laue-Str. 9, D-60438 Frankfurt/Main, Germany
/ Franz Tumulka
  • Institute of Biochemistry, Biocenter, Goethe University Frankfurt, Max-von-Laue-Str. 9, D-60438 Frankfurt/Main, Germany
/ Rupert Abele
  • Institute of Biochemistry, Biocenter, Goethe University Frankfurt, Max-von-Laue-Str. 9, D-60438 Frankfurt/Main, Germany
  • Email:
Published Online: 2011-06-18 | DOI: https://doi.org/10.1515/bc.2011.007

Abstract

The transporter associated with antigen processing-like (TAPL) is a polypeptide transporter translocating cytosolic peptides into the lumen of lysosomes driven by ATP hydrolysis. TAPL belongs to the family of ABC transporters and forms a homodimer. This ABC transporter not only shows a broad tissue but also a wide phylogenetic distribution, because orthologs are still found in nematodes and insects. Here, we present the topology, substrate specificity, and distribution of this intracellular polypeptide transporter. Additionally, we will discuss its proposed physiological functions such as housekeeping together with a specialized factor for metabolite storage as well as for the adaptive immunity.

Keywords: antigen processing; lysosomes; peptide specificity; peptide transport; subcellular targeting; truncation

About the article

Corresponding author


Received: 2010-08-27

Accepted: 2010-10-06

Published Online: 2011-06-18

Published in Print: 2011-02-01



Citation Information: Biological Chemistry, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/bc.2011.007. Export Citation

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