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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred

12 Issues per year


IMPACT FACTOR 2016: 3.273

CiteScore 2016: 3.01

SCImago Journal Rank (SJR) 2016: 1.679
Source Normalized Impact per Paper (SNIP) 2016: 0.800

Online
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1437-4315
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Volume 392, Issue 1-2 (Feb 2011)

Issues

SLC22 transporter family proteins as targets for cytostatic uptake into tumor cells

Shivangi Gupta
  • Abteilung Vegetative Physiologie und Pathophysiologie, Georg-August-Universität, Humboldallee 23, D-37073 Göttingen, Germany
  • Other articles by this author:
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/ Gerhard Burckhardt
  • Abteilung Vegetative Physiologie und Pathophysiologie, Georg-August-Universität, Humboldallee 23, D-37073 Göttingen, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Yohannes Hagos
  • Abteilung Vegetative Physiologie und Pathophysiologie, Georg-August-Universität, Humboldallee 23, D-37073 Göttingen, Germany
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Published Online: 2011-06-18 | DOI: https://doi.org/10.1515/bc.2011.014

Abstract

The response to chemotherapy by tumor cells depends on the concentration of cytostatics accumulated inside the cells. The accumulation of anticancer drugs in tumor cells is mainly dependent on functional expression of efflux and influx transporters and to a minor extent on passive diffusion through the membrane. Efflux transporters of the ABC family are partially responsible for the chemoresistance of cancer cells by secreting these cytostatics. Over the past decades, the role of ABC transporters in the chemoresistance of various malignant tumors has been very well documented. By contrast, very little is known about the impact on tumor therapy of influx transporters belonging to the solute carrier transporters (SLC family). In this review, we focus on the interaction of SLC22 transporters with cytostatics, the expression of these transporters in tumor cells as well as their impact on the chemosensitivity of cancer cells.

Keywords: chemosensitivity; cytostatics; organic anion transporter; organic cation transporter; SLC22A transporter; uptake transporter

About the article

Corresponding author


Received: 2010-08-11

Accepted: 2010-10-25

Published Online: 2011-06-18

Published in Print: 2011-02-01


Citation Information: Biological Chemistry, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/bc.2011.014.

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