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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred

12 Issues per year


IMPACT FACTOR 2016: 3.273

CiteScore 2016: 3.01

SCImago Journal Rank (SJR) 2016: 1.679
Source Normalized Impact per Paper (SNIP) 2016: 0.800

Online
ISSN
1437-4315
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Volume 392, Issue 11 (Nov 2011)

Issues

mRNA expression levels of the biological factors uPAR, uPAR-del4/5, and rab31, displaying prognostic value in breast cancer, are not clinically relevant in advanced ovarian cancer

Matthias Kotzsch / Julia Dorn
  • Klinische Forschergruppe der Frauenklinik, Technische Universität München, D-81675 München, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Kristina Doetzer
  • Klinische Forschergruppe der Frauenklinik, Technische Universität München, D-81675 München, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Barbara Schmalfeldt
  • Klinische Forschergruppe der Frauenklinik, Technische Universität München, D-81675 München, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Janna Krol
  • Klinische Forschergruppe der Frauenklinik, Technische Universität München, D-81675 München, Germany
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  • De Gruyter OnlineGoogle Scholar
/ Gustavo Baretton / Marion Kiechle
  • Klinische Forschergruppe der Frauenklinik, Technische Universität München, D-81675 München, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Manfred Schmitt
  • Klinische Forschergruppe der Frauenklinik, Technische Universität München, D-81675 München, Germany
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  • De Gruyter OnlineGoogle Scholar
/ Viktor Magdolen
Published Online: 2011-08-18 | DOI: https://doi.org/10.1515/BC.2011.166

Abstract

High tumor tissue mRNA expression of the tumor biological factors uPAR, uPAR-del4/5, or rab31 is associated with shorter distant metastasis-free and overall survival in breast cancer patients. To evaluate whether these factors are also clinically relevant in ovarian cancer, we quantified the respective mRNA levels in primary tumor tissue of advanced ovarian cancer patients (n=103) and evaluated their association with clinicopathological parameters and patients’ prognosis. mRNA expression levels of all three markers did not show any significant association with overall or progression-free survival, demonstrating that these factors have no prognostic value in advanced ovarian cancer.

Keywords: ovarian cancer; prognosis; quantitative PCR; rab31; uPAR; uPAR-del4/5

About the article

Corresponding author


Received: 2011-05-26

Accepted: 2011-08-11

Published Online: 2011-08-18

Published in Print: 2011-11-01


Citation Information: Biological Chemistry, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2011.166.

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