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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Turk, Boris / Wittinghofer, Alfred

12 Issues per year


IMPACT FACTOR 2015: 2.710
Rank 142 out of 289 in category Biochemistry & Molecular Biology in the 2015 Thomson Reuters Journal Citation Report/Science Edition

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Online
ISSN
1437-4315
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Volume 392, Issue 11 (Nov 2011)

Issues

mRNA expression levels of the biological factors uPAR, uPAR-del4/5, and rab31, displaying prognostic value in breast cancer, are not clinically relevant in advanced ovarian cancer

Matthias Kotzsch
  • Institut für Pathologie, Technische Universität Dresden, D-01307 Dresden, Germany
/ Julia Dorn
  • Klinische Forschergruppe der Frauenklinik, Technische Universität München, D-81675 München, Germany
/ Kristina Doetzer
  • Klinische Forschergruppe der Frauenklinik, Technische Universität München, D-81675 München, Germany
/ Barbara Schmalfeldt
  • Klinische Forschergruppe der Frauenklinik, Technische Universität München, D-81675 München, Germany
/ Janna Krol
  • Klinische Forschergruppe der Frauenklinik, Technische Universität München, D-81675 München, Germany
/ Gustavo Baretton
  • Institut für Pathologie, Technische Universität Dresden, D-01307 Dresden, Germany
/ Marion Kiechle
  • Klinische Forschergruppe der Frauenklinik, Technische Universität München, D-81675 München, Germany
/ Manfred Schmitt
  • Klinische Forschergruppe der Frauenklinik, Technische Universität München, D-81675 München, Germany
/ Viktor Magdolen
  • Klinische Forschergruppe der Frauenklinik, Technische Universität München, D-81675 München, Germany
  • Email:
Published Online: 2011-08-18 | DOI: https://doi.org/10.1515/BC.2011.166

Abstract

High tumor tissue mRNA expression of the tumor biological factors uPAR, uPAR-del4/5, or rab31 is associated with shorter distant metastasis-free and overall survival in breast cancer patients. To evaluate whether these factors are also clinically relevant in ovarian cancer, we quantified the respective mRNA levels in primary tumor tissue of advanced ovarian cancer patients (n=103) and evaluated their association with clinicopathological parameters and patients’ prognosis. mRNA expression levels of all three markers did not show any significant association with overall or progression-free survival, demonstrating that these factors have no prognostic value in advanced ovarian cancer.

Keywords: ovarian cancer; prognosis; quantitative PCR; rab31; uPAR; uPAR-del4/5

About the article

Corresponding author


Received: 2011-05-26

Accepted: 2011-08-11

Published Online: 2011-08-18

Published in Print: 2011-11-01


Citation Information: Biological Chemistry, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2011.166. Export Citation

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