Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred

IMPACT FACTOR 2017: 3.022

CiteScore 2017: 2.81

SCImago Journal Rank (SJR) 2017: 1.562
Source Normalized Impact per Paper (SNIP) 2017: 0.705

See all formats and pricing
More options …
Volume 392, Issue 12


Cysteine proteinase SpeB from Streptococcus pyogenes – a potent modifier of immunologically important host and bacterial proteins

Daniel C. Nelson
  • Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, MD, USA
  • Department of Veterinary Medicine, Virginia-Maryland Regional College of Veterinary Medicine, College Park, MD, USA
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Julia Garbe
  • Division of Infection Medicine, Department of Clinical Sciences, Lund University, Lund, Sweden
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Mattias Collin


Group A streptococcus (Streptococcus pyogenes) is an exclusively human pathogen that causes a wide spectrum of diseases ranging from pharyngitis, to impetigo, to toxic shock, to necrotizing fasciitis. The diversity of these disease states necessitates that S. pyogenes possess the ability to modulate both the innate and adaptive immune responses. SpeB, a cysteine proteinase, is the predominant secreted protein from S. pyogenes. Because of its relatively indiscriminant specificity, this enzyme has been shown to degrade the extracellular matrix, cytokines, chemokines, complement components, immunoglobulins, and serum protease inhibitors, to name but a few of the known substrates. Additionally, SpeB regulates other streptococcal proteins by degrading them or releasing them from the bacterial surface. Despite the wealth of literature on putative SpeB functions, there remains much controversy about this enzyme because many of reported activities would produce contradictory physiological results. Here we review all known host and bacterial protein substrates for SpeB, their cleavage sites, and discuss the role of this enzyme in streptococcal pathogenesis based on the current literature.

Keywords: animal models; C10 cysteine proteinase; human infection; immune evasion; proteolysis; SpeB; streptococcal cysteine proteinase; streptopain; virulence

About the article

Corresponding authors

Received: 2011-09-05

Accepted: 2011-09-26

Published in Print: 2011-12-01

Citation Information: Biological Chemistry, Volume 392, Issue 12, Pages 1077–1088, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2011.208.

Export Citation

©2011 by Walter de Gruyter Berlin Boston.Get Permission

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Nicola Horstmann, Chau Nguyen Tran, Chelcy Brumlow, Sruti DebRoy, Hui Yao, Graciela Nogueras Gonzalez, Nishanth Makthal, Muthiah Kumaraswami, Samuel A. Shelburne, and Michael R. Wessels
PLOS Pathogens, 2018, Volume 14, Number 10, Page e1007354
Laura Broglia, Solange Materne, Anne-Laure Lécrivain, Karin Hahnke, Anaïs Le Rhun, and Emmanuelle Charpentier
RNA Biology, 2018, Page 1
G. C. Port, L. A. Vega, A. B. Nylander, and M. G. Caparon
Journal of Bacteriology, 2014, Volume 196, Number 14, Page 2563
Helena Persson, Reine Vindebro, Ulrich von Pawel-Rammingen, and A. Camilli
Infection and Immunity, 2013, Volume 81, Number 6, Page 2236
K. J. Pflughoeft, M. C. Swick, D. A. Engler, H.-J. Yeo, and T. M. Koehler
Journal of Bacteriology, 2014, Volume 196, Number 2, Page 424
Shiou-Ling Lu, Chih-Feng Kuo, Hao-Wen Chen, Yi-Shuan Yang, Ching-Chuan Liu, Robert Anderson, Jiunn-Jong Wu, and Yee-Shin Lin
mBio, 2015, Volume 6, Number 5
Karthickeyan Chella Krishnan, Santhosh Mukundan, Julio A. Landero Figueroa, Joseph A. Caruso, Malak Kotb, and A. Camilli
Infection and Immunity, 2014, Volume 82, Number 7, Page 2992
Natesan Balasubramanian, Govintharaj Varatharaju, Vellasamy Shanmugaiah, Karuppiah Balakrishnan, and Mandayam A. Thirunarayan
Frontiers in Microbiology, 2018, Volume 9
Stephan Brouwer, Amanda J. Cork, Cheryl-Lynn Y. Ong, Timothy C. Barnett, Nicholas P. West, Kevin S. McIver, Mark J. Walker, and Olaf Schneewind
Journal of Bacteriology, 2018, Volume 200, Number 8, Page e00654-17
Anshu Babbar, Andreas Itzek, Dietmar H. Pieper, and D. Patric Nitsche-Schmitz
Folia Microbiologica, 2018
Tomoko Sumitomo, Yasushi Mori, Yuumi Nakamura, Mariko Honda-Ogawa, Seitaro Nakagawa, Masaya Yamaguchi, Hiroyuki Matsue, Yutaka Terao, Masanobu Nakata, and Shigetada Kawabata
Frontiers in Cellular and Infection Microbiology, 2018, Volume 8
J Andrés Valderrama and Victor Nizet
Future Microbiology, 2017
Sonja Oehmcke-Hecht, Leif E. Nass, Jan B. Wichura, Stefan Mikkat, Bernd Kreikemeyer, and Tomas Fiedler
Frontiers in Microbiology, 2017, Volume 8
Nippon Saikingaku Zasshi, 2017, Volume 72, Number 3, Page 213
David Pérez-Pascual, Aurelie Lunazzi, Ghislaine Magdelenat, Zoe Rouy, Alain Roulet, Celine Lopez-Roques, Robert Larocque, Tristan Barbeyron, Angélique Gobet, Gurvan Michel, Jean-François Bernardet, and Eric Duchaud
Frontiers in Microbiology, 2017, Volume 8
Tomoko Sumitomo, Masanobu Nakata, Miharu Higashino, Yutaka Terao, and Shigetada Kawabata
Journal of Biological Chemistry, 2013, Volume 288, Number 19, Page 13317
Z. Chen, L. Mashburn-Warren, J. Merritt, M.J. Federle, and J. Kreth
Molecular Oral Microbiology, 2017
Anhphan T. Ly, John P. Noto, Odaelys L. Walwyn, Robert R. Tanz, Stanford T. Shulman, William Kabat, Debra E. Bessen, and Sean Reid
PLOS ONE, 2017, Volume 12, Number 5, Page e0177784
Derek Fleming and Kendra Rumbaugh
Microorganisms, 2017, Volume 5, Number 2, Page 15
Мазепа, Andrey Mazepa, Марков, Evgeniy Markov, Козлов, Stanislav Kozlov, Николаев, Valeriy Nikolaev, Корнева, Aleksandra Korneva, Попова, and Yuliya Popova
Бюллетень Восточно-Сибирского научного центра Сибирского отделения Российской академии медицинских наук, 2016, Volume 1, Number 5, Page 155
Chih-Feng Kuo, Nina Tsao, I-Chen Hsieh, Yee-Shin Lin, Jiunn-Jong Wu, Yu-Ting Hung, and Paulo Lee Ho
PLOS ONE, 2017, Volume 12, Number 3, Page e0174464
Valeria Cafardi, Massimiliano Biagini, Manuele Martinelli, Rosanna Leuzzi, Jeffrey T. Rubino, Francesca Cantini, Nathalie Norais, Maria Scarselli, Davide Serruto, Meera Unnikrishnan, and Mikael Skurnik
PLoS ONE, 2013, Volume 8, Number 11, Page e81306
Nina Tsao, Miao-Hui Cheng, Hsiu-Chen Yang, Yu-Chieh Wang, Yi-Ling Liu, Chih-Feng Kuo, and Daniela Flavia Hozbor
PLoS ONE, 2013, Volume 8, Number 1, Page e55028
Chih-Feng Kuo, Nina Tsao, Miao-Hui Cheng, Hsiu-Chen Yang, Yu-Chieh Wang, Ying-Pin Chen, Kai-Jen Lin, and Sean D. Reid
PLOS ONE, 2015, Volume 10, Number 1, Page e0117268
Poulomee Sarkar and Paul Sumby
Molecular Microbiology, 2017, Volume 103, Number 4, Page 576
Julia Uhlmann, Nikolai Siemens, Ylva Kai-Larsen, Tomas Fiedler, Peter Bergman, Linda Johansson, and Anna Norrby-Teglund
Journal of Infectious Diseases, 2016, Volume 214, Number 12, Page 1876
Christopher N. LaRock, Jordan Todd, Doris L. LaRock, Joshua Olson, Anthony J. O’Donoghue, Avril A. B. Robertson, Matthew A. Cooper, Hal M. Hoffman, and Victor Nizet
Science Immunology, 2016, Volume 1, Number 2, Page eaah3539
Nikolai Siemens, Bhavya Chakrakodi, Srikanth Mairpady Shambat, Marina Morgan, Helena Bergsten, Ole Hyldegaard, Steinar Skrede, Per Arnell, Martin B. Madsen, Linda Johansson, Julius Juarez, Lidija Bosnjak, Matthias Mörgelin, Mattias Svensson, and Anna Norrby-Teglund
JCI Insight, 2016, Volume 1, Number 10
Chia-Ling Chen, Yueh-Ying Wu, Chiou-Feng Lin, Chih-Feng Kuo, Chia-Li Han, Shuying Wang, Woei-Jer Chuang, Chiu-Yueh Chen, Jiunn-Jong Wu, Pei-Jane Tsai, Ching-Chuan Liu, and Yee-Shin Lin
Scientific Reports, 2016, Volume 6, Number 1
Hwang-Soo Joo, Chih-Iung Fu, and Michael Otto
Philosophical Transactions of the Royal Society B: Biological Sciences, 2016, Volume 371, Number 1695, Page 20150292
Jonathan Sjögren, Fredrik Olsson, and Alain Beck
The Analyst, 2016, Volume 141, Number 11, Page 3114
Cuiming Cao, Fang Zhang, Mingyu Ji, Fengyan Pei, Xiujie Fan, Hong Shen, Qingxi Wang, Weihua Yang, and Yunshan Wang
Toxicon, 2016, Volume 117, Page 53
Mohsen Arzanlou
Microbial Pathogenesis, 2016, Volume 93, Page 166
Márcia Dinis, Céline Plainvert, Magalie Longo, Julie Guignot, Christelle Gabriel, Claire Poyart, Agnès Fouet, and Richard Marconi
Pathogens and Disease, 2016, Volume 74, Number 2, Page ftv124
Timothy C. Barnett, Jason N. Cole, Tania Rivera-Hernandez, Anna Henningham, James C. Paton, Victor Nizet, and Mark J. Walker
Cellular Microbiology, 2015, Volume 17, Number 12, Page 1721
Helena Persson, Jenny Johansson Söderberg, Reine Vindebro, Björn P. Johansson, and Ulrich von Pawel-Rammingen
Molecular Immunology, 2015, Volume 68, Number 2, Page 176
Jonas Lannergård, Bodil M. Kristensen, Mattias C. U. Gustafsson, Jenny J. Persson, Anna Norrby-Teglund, Margaretha Stålhammar-Carlemalm, and Gunnar Lindahl
MicrobiologyOpen, 2015, Volume 4, Number 5, Page 774
Sashi Kant, Shivani Agarwal, Preeti Pancholi, and Vijay Pancholi
Molecular Microbiology, 2015, Volume 97, Number 3, Page 515
Ichiro Nakagawa
Cell Host & Microbe, 2013, Volume 14, Number 6, Page 604
Timothy C. Barnett, David Liebl, Lisa M. Seymour, Christine M. Gillen, Jin Yan Lim, Christopher N. LaRock, Mark R. Davies, Benjamin L. Schulz, Victor Nizet, Rohan D. Teasdale, and Mark J. Walker
Cell Host & Microbe, 2013, Volume 14, Number 6, Page 675
Christopher N. LaRock and Victor Nizet
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2015, Volume 1848, Number 11, Page 3047
Lucy E M Lamb, Shiranee Sriskandan, and Lionel K K Tan
The Lancet Infectious Diseases, 2015, Volume 15, Number 1, Page 109
Debra E. Bessen, W. Michael McShan, Scott V. Nguyen, Amol Shetty, Sonia Agrawal, and Hervé Tettelin
Infection, Genetics and Evolution, 2015, Volume 33, Page 393
Angela H. Nobbs, Howard F. Jenkinson, and Dean B. Everett
Infection, Genetics and Evolution, 2015, Volume 33, Page 361
Juan Cristobal Jimenez and Michael J. Federle
Frontiers in Cellular and Infection Microbiology, 2014, Volume 4
Yukihiko Saeki and Katsuhiko Ishihara
Autoimmunity Reviews, 2014, Volume 13, Number 10, Page 1064
Jung Mogg Kim
Intestinal Research, 2014, Volume 12, Number 1, Page 20
Rebecca J. Burke and Christopher Chang
Autoimmunity Reviews, 2014, Volume 13, Number 4-5, Page 503
Joanna Koziel and Jan Potempa
Cell and Tissue Research, 2013, Volume 351, Number 2, Page 325

Comments (0)

Please log in or register to comment.
Log in