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Thomas, Douglas D.

Biological Chemistry

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Volume 392, Issue 8-9 (Aug 2011)


Septin genomics: a road less travelled

S.E. Hilary Russell
  • Centre for Cancer Research and Cell Biology, Queens University Belfast, Belfast, Northern Ireland, UK
  • Email:
/ Peter A. Hall
  • Departments of Molecular Oncology and Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Centre, P.O. Box 3354, Riyadh, 11211, Saudi Arabia
  • College of Medicine, Alfaisal University, P.O. Box 50927, Riyadh 11533, Saudi Arabia


The human septins are part of a gene family, that is a group of genes with similar sequences and usually but not invariably share similar functions that are descended from a common ancestor. Here we review our current knowledge of the human septin gene family and highlight areas of uncertainty. Currently 13 human septin genes are known (SEPT1 to SEPT12 and SEPT14). What was known as SEPT13 is now defined as one of many SEPT7 related pseudogenes. The family is characterized by complex genomics and extensive (but not universal) splicing, giving rise to a plethora of septin isoforms. For only a few members of the family do we have a comprehensive insight into these transcripts and isoforms. Given the formation of countless septin homotypic and heterotypic interactions our understanding of the biology and pathobiology of the septin family will require a detailed understanding of the genomics, transcriptomics and regulation of all members of this diverse and complex family.

Keywords: gene family; nonsense mediated decay; pseudogene; regulation; septin; transcripts

About the article

Corresponding author

Received: 2011-05-13

Accepted: 2011-06-17

Published in Print: 2011-08-01

Citation Information: Biological Chemistry, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2011.079. Export Citation

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