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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred

12 Issues per year


IMPACT FACTOR 2017: 3.022

CiteScore 2017: 2.81

SCImago Journal Rank (SJR) 2017: 1.562
Source Normalized Impact per Paper (SNIP) 2017: 0.705

Online
ISSN
1437-4315
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Volume 393, Issue 1-2

Issues

Transporters in cholelithiasis

Caroline S. Stokes
  • Department of Medicine II, Saarland University Medical Center, Kirrberger Str. 1, D-66421 Homburg, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Frank Lammert
Published Online: 2012-01-04 | DOI: https://doi.org/10.1515/BC-2011-226

Abstract

Gallstones are a common and costly disease with a projected increase in prevalence due to the increasing ageing population. Numerous endogenous and environmental factors are aetiologically related to this multifactorial disease, and genetic studies continue to unravel the pathobiological mechanisms related to gallstone formation. In particular, variants of genes encoding hepatobiliary transporters have been implicated in gallstone disease and, given their ability to influence biliary lipid composition, have undergone considerable investigation. Here we summarize the role of enterohepatic transporters in cholelithogenesis with a particular focus on pertinent ATP-binding cassette transporters (ABCB4, ABCB11, ABCC7, and ABCG5/G8).

Keywords: ABC transporters; bile; gallstones; genome-wide association studies; lithogenic genes; multifactorial disease

About the article

Corresponding author


Received: 2011-10-04

Accepted: 2011-10-27

Published Online: 2012-01-04

Published in Print: 2012-01-01


Citation Information: Biological Chemistry, Volume 393, Issue 1-2, Pages 3–10, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC-2011-226.

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