Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred

IMPACT FACTOR 2017: 3.022

CiteScore 2017: 2.81

SCImago Journal Rank (SJR) 2017: 1.562
Source Normalized Impact per Paper (SNIP) 2017: 0.705

See all formats and pricing
More options …
Volume 393, Issue 1-2


Transporters in cholelithiasis

Caroline S. Stokes
  • Department of Medicine II, Saarland University Medical Center, Kirrberger Str. 1, D-66421 Homburg, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Frank Lammert
Published Online: 2012-01-04 | DOI: https://doi.org/10.1515/BC-2011-226


Gallstones are a common and costly disease with a projected increase in prevalence due to the increasing ageing population. Numerous endogenous and environmental factors are aetiologically related to this multifactorial disease, and genetic studies continue to unravel the pathobiological mechanisms related to gallstone formation. In particular, variants of genes encoding hepatobiliary transporters have been implicated in gallstone disease and, given their ability to influence biliary lipid composition, have undergone considerable investigation. Here we summarize the role of enterohepatic transporters in cholelithogenesis with a particular focus on pertinent ATP-binding cassette transporters (ABCB4, ABCB11, ABCC7, and ABCG5/G8).

Keywords: ABC transporters; bile; gallstones; genome-wide association studies; lithogenic genes; multifactorial disease

About the article

Corresponding author

Received: 2011-10-04

Accepted: 2011-10-27

Published Online: 2012-01-04

Published in Print: 2012-01-01

Citation Information: Biological Chemistry, Volume 393, Issue 1-2, Pages 3–10, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC-2011-226.

Export Citation

©2012 by Walter de Gruyter Berlin Boston.Get Permission

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Meijing Liu, Changhui Liu, Hao Chen, Xiaotao Huang, Xiaohui Zeng, Juncheng Zhou, and Suiqing Mi
European Journal of Pharmacology, 2017, Volume 815, Page 1
Yoichiro Asai, Tetsuya Yamada, Sohei Tsukita, Kei Takahashi, Masamitsu Maekawa, Midori Honma, Masanori Ikeda, Keigo Murakami, Yuichiro Munakata, Yuta Shirai, Shinjiro Kodama, Takashi Sugisawa, Yumiko Chiba, Yasuteru Kondo, Keizo Kaneko, Kenji Uno, Shojiro Sawada, Junta Imai, Yasuhiro Nakamura, Hiroaki Yamaguchi, Kozo Tanaka, Hironobu Sasano, Nariyasu Mano, Yoshiyuki Ueno, Tooru Shimosegawa, and Hideki Katagiri
Gastroenterology, 2017, Volume 152, Number 6, Page 1521
Ibrahim Guillermo Castro-Torres, René de Jesús Cárdenas-Vázquez, Claudia Velázquez-González, Rosa Ventura-Martínez, Minarda De la O-Arciniega, Elia Brosla Naranjo-Rodríguez, and Mariano Martínez-Vázquez
European Journal of Pharmacology, 2015, Volume 765, Page 366
György Várady, Judit Cserepes, Adrienn Németh, Edit Szabó, and Balázs Sarkadi
Biomarkers in Medicine, 2013, Volume 7, Number 5, Page 803

Comments (0)

Please log in or register to comment.
Log in