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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred


IMPACT FACTOR 2017: 3.022

CiteScore 2017: 2.81

SCImago Journal Rank (SJR) 2017: 1.562
Source Normalized Impact per Paper (SNIP) 2017: 0.705

Online
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1437-4315
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Volume 393, Issue 11

Issues

Oligomerization of polytopic α-helical membrane proteins: causes and consequences

Florian Cymer
  • Corresponding author
  • Institut für Pharmazie und Biochemie, Johannes Gutenberg-Universität Mainz, Johann-Joachim-Becher-Weg 30, D-55128 Mainz, Deutschland
  • Present address: University of Stockholm, Department of Biochemistry and Biophysics, Svante Arrhenius väg 16 C, S-10691 Stockholm, Sweden
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  • Other articles by this author:
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/ Dirk Schneider
  • Institut für Pharmazie und Biochemie, Johannes Gutenberg-Universität Mainz, Johann-Joachim-Becher-Weg 30, D-55128 Mainz, Deutschland
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2012-10-11 | DOI: https://doi.org/10.1515/hsz-2012-0231

Abstract

Several polytopic α-helical membrane-integrated proteins appear to be organized in higher-ordered oligomeric complexes. While many aspects are still enigmatic, in recent years, the physiological impact of membrane protein oligomerization has been analyzed to some extent. In the present article, oligomerization of structurally well-defined membrane proteins is discussed. The available experimental information indicates the causes and physiological consequences of membrane protein oligomerization, including stabilization, cooperative functions, and control of specific activities. Based on the currently available observations, we aim to derive some general principles and discuss open questions.

Keywords: α-helical; channel; function; GPCR; membrane protein; structure

About the article

Florian Cymer

Florian Cymer studied biology at the University of Frankfurt and Ulm. He then joined the group of Prof. Dr. Dirk Schneider as a PhD student, and investigated the in vitro and in vivo oligomerization of membrane proteins. He received his PhD in 2010 from the University of Freiburg and joined the group of Prof. Dr. Gunnar von Heijne at the University of Stockholm as a Postdoc. He currently focusses on the membrane insertion and folding of bacterial and mammalian polytopic membrane proteins.

Dirk Schneider

After studies in chemistry and biology at the University of Münster, Dirk Schneider obtained his PhD from the University of Bochum in 2000. Thereafter, he joined the laboratory of Prof. Dr. D.M. Engelman at Yale University. From 2003 to 2009 he was assistant professor of biochemistry at the University of Freiburg, and since 2010 he is a full professor of biochemistry at the University of Mainz. His research focuses on membrane protein folding and protein-lipid interactions.


Corresponding author: Florian Cymer, Institut für Pharmazie und Biochemie, Johannes Gutenberg-Universit ät Mainz, Johann-Joachim-Becher-Weg 30, D-55128 Mainz, Deutschland


Received: 2012-06-21

Accepted: 2012-09-03

Published Online: 2012-10-11

Published in Print: 2012-11-01


Citation Information: , Volume 393, Issue 11, Pages 1215–1230, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/hsz-2012-0231.

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