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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred


IMPACT FACTOR 2017: 3.022

CiteScore 2017: 2.81

SCImago Journal Rank (SJR) 2017: 1.562
Source Normalized Impact per Paper (SNIP) 2017: 0.705

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1437-4315
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Volume 393, Issue 12

Issues

Integration of cellular bioenergetics with mitochondrial quality control and autophagy

Bradford G. Hill
  • Diabetes and Obesity Center, Institute of Molecular Cardiology, and Department of Medicine, University of Louisville, Louisville, KY, USA
  • Departments of Biochemistry and Molecular Biology and Physiology and Biophysics, University of Louisville, Louisville, KY, USA
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Gloria A. Benavides
  • Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
  • Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Jack R. Lancaster Jr.
  • Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
  • Department of Anesthesiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
  • Department of Physiology and Biophysics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
  • Department of Environmental Health Sciences, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Scott Ballinger
  • Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
  • Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
  • Center for Heart Failure Research, University of Alabama at Birmingham, Birmingham, AL 35294, USA
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Lou Dell’Italia
  • Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
  • Center for Heart Failure Research, University of Alabama at Birmingham, Birmingham, AL 35294, USA
  • Department of Veteran Affairs Medical Center, Birmingham, AL 35294, USA
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Jianhua Zhang
  • Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
  • Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
  • Department of Veteran Affairs Medical Center, Birmingham, AL 35294, USA
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Victor M. Darley-Usmar
  • Corresponding author
  • Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
  • Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
  • Department of Environmental Health Sciences, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
  • Center for Heart Failure Research, University of Alabama at Birmingham, Birmingham, AL 35294, USA
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2012-11-13 | DOI: https://doi.org/10.1515/hsz-2012-0198

Abstract

Bioenergetic dysfunction is emerging as a cornerstone for establishing a framework for understanding the pathophysiology of cardiovascular disease, diabetes, cancer and neurodegeneration. Recent advances in cellular bioenergetics have shown that many cells maintain a substantial bioenergetic reserve capacity, which is a prospective index of ‘healthy’ mitochondrial populations. The bioenergetics of the cell are likely regulated by energy requirements and substrate availability. Additionally, the overall quality of the mitochondrial population and the relative abundance of mitochondria in cells and tissues also impinge on overall bioenergetic capacity and resistance to stress. Because mitochondria are susceptible to damage mediated by reactive oxygen/nitrogen and lipid species, maintaining a ‘healthy’ population of mitochondria through quality control mechanisms appears to be essential for cell survival under conditions of pathological stress. Accumulating evidence suggest that mitophagy is particularly important for preventing amplification of initial oxidative insults, which otherwise would further impair the respiratory chain or promote mutations in mitochondrial DNA (mtDNA). The processes underlying the regulation of mitophagy depend on several factors, including the integrity of mtDNA, electron transport chain activity, and the interaction and regulation of the autophagic machinery. The integration and interpretation of cellular bioenergetics in the context of mitochondrial quality control and genetics is the theme of this review.

Keywords: cardiovascular disease; haplotypes; mitophagy; neurodegenerative disease; spare respiratory capacity; xanthine oxidase

About the article

Bradford G. Hill

Bradford G. Hill received his PhD in Biochemistry from the University of Louisville. He completed postdoctoral training in mitochondrial biology in the laboratory of Victor Darley-Usmar at the University of Alabama-Birmingham before moving to U of L as an Assistant Professor of Medicine in the Center for Diabetes and Obesity Research. Dr. Hill’s research focuses on understanding the role of intermediary metabolism in cardiovascular health and disease. The long-term objective of these studies is to identify derangements in metabolism that underlie the development of obesity and cardiovascular disease and to target these metabolic processes therapeutically.

Gloria A. Benavides

Gloria A. Benavides holds a BSc in Clinical Chemist, and a MSc and a PhD in Biomedical Chemistry from the Autonomous University of Nuevo Leon, Mexico. She was a Visiting Scholar in the Chemistry Department of Louisiana State University (1998–1999) and the Pharmacognosy Department in The University of Mississippi (2001); a Postdoctoral Researcher in the Departments of Environmental Health Sciences (2004–2007) and Pathology (2007–2011), and is currently a Research Associate in the Pathology Department at University of Alabama at Birmingham (2011–current).

Jack R. Lancaster Jr.

Jack R. Lancaster received his PhD in Biochemistry from the University of Tennessee Health Sciences Center, and pursued postdoctoral work at Cornell and Duke universities. He assumed faculty positions in the Department of Chemistry and Biochemistry, Utah State University; Department of Surgery, University of Pittsburgh; Department of Physiology, LSU Health Sciences Center New Orleans; and the Department of Anesthesiology, University of Alabama at Birmingham. His research focus is on the chemical and physical foundations of the biological actions of nitric oxide.

Scott Ballinger

Scott Ballinger received his undergraduate degrees from Texas A&M University and his PhD in Biochemistry from Emory University. He completed postdoctoral training at the University of Vermont’s Genetics and Toxicology Laboratory, as an Environmental Pathology Fellow and as a Department of Energy Alexander Hollaender Distinguished Fellow. He is currently a Professor of Pathology in the Division of Molecular and Cellular Pathology, Department of Pathology and a senior scientist in the Center for Free Radical Biology at the University of Alabama at Birmingham. His laboratory studies the role of the mitochondrion and its genetics upon influencing disease susceptibility with focus upon diseases influenced by the environment, particularly the cardiometabolic diseases.

Lou Dell’Italia

Louis Dell’Italia received his MD and subsequent Internal Medicine training at Georgetown University and his Cardiology Fellowship Training at the University of Texas Health Science Center at San Antonio (UTSA). He served as Cardiology Faculty at UTSA and moved to the University of Alabama-Birmingham (UAB) where he has been since 1988 serving as a staff physician at the Birmingham VA Medical Center and Faculty at the UAB School of Medicine in the Department of Medicine and Division of Cardiovascular Disease. Dr. Dell’Italia’s research focuses on understanding the molecular and cellular mechanisms in the pathophysiology of a pure volume overload of the heart, in particular in patients with mitral regurgitation.

Jianhua Zhang

Jianhua Zhang was trained at University of Texas Medical Center at Dallas for her PhD. She then completed her postdoctoral studies at the Whitehead Institute for Biomedical Research. She was appointed to her first faculty position at University of Cincinnati Medical Center. In 2005 she joined the University of Alabama at Birmingham where she is now an Associate Professor in the Department of Pathology. She leads a research program to understand the mechanisms of apoptosis and autophagy in neurodegeneration.

Victor M. Darley-Usmar

Victor M. Darley-Usmar is presently Professor of Pathology and Director of the UAB Center for Free Radical Biology at UAB. In this role, he is able to combine major research interests in mitochondriology and reactive oxygen and nitrogen species with a pursuit of an understanding of the mechanisms of cell death in cardiovascular disease. He was trained as biochemist at the University of Essex in England and then moved to the University of Oregon to pursue his interests in the structure and function of mitochondrial proteins in human disease. After a period as a lecturer in Japan and a Research Scientist at the Wellcome Research Foundation in London he joined UAB to establish his own research group in the Department of Pathology.


Corresponding author: Victor M. Darley-Usmar, Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA


Received: 2012-05-13

Accepted: 2012-06-22

Published Online: 2012-11-13

Published in Print: 2012-12-01


Citation Information: Biological Chemistry, Volume 393, Issue 12, Pages 1485–1512, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/hsz-2012-0198.

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Free Radical Biology and Medicine, 2014, Volume 77, Page 1
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Samantha Giordano, Matthew Dodson, Saranya Ravi, Matthew Redmann, Xiaosen Ouyang, Victor M. Darley Usmar, and Jianhua Zhang
Journal of Neurochemistry, 2014, Volume 131, Number 5, Page 625
[91]
Anurag Agrawal and Y.S. Prakash
Immunology and Allergy Clinics of North America, 2014, Volume 34, Number 4, Page 785
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Sian M. Henson, Alessio Lanna, Natalie E. Riddell, Ornella Franzese, Richard Macaulay, Stephen J. Griffiths, Daniel J. Puleston, Alexander Scarth Watson, Anna Katharina Simon, Sharon A. Tooze, and Arne N. Akbar
Journal of Clinical Investigation, 2014, Volume 124, Number 9, Page 4004
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Ana Gabriela Jimenez and Joseph B. Williams
Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 2014, Volume 176, Page 41
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Mariana Appel Hort, Marcos Raniel Straliotto, Jade de Oliveira, Nívea Dias Amoêdo, João Batista Teixeira da Rocha, Antônio Galina, Rosa Maria Ribeiro-do-Valle, and Andreza Fabro de Bem
Biochimie, 2014, Volume 105, Page 172
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Peter Y. Chuang, Jin Xu, Yan Dai, Fu Jia, Sandeep K. Mallipattu, Rabi Yacoub, Leyi Gu, Prem K. Premsrirut, and John C. He
The American Journal of Pathology, 2014, Volume 184, Number 7, Page 1940
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Balu K. Chacko, Philip A. Kramer, Saranya Ravi, Gloria A. Benavides, Tanecia Mitchell, Brian P. Dranka, David Ferrick, Ashwani K. Singal, Scott W. Ballinger, Shannon M. Bailey, Robert W. Hardy, Jianhua Zhang, Degui Zhi, and Victor M. Darley-Usmar
Clinical Science, 2014, Volume 127, Number 6, Page 367
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Giulia Ambrosi, Cristina Ghezzi, Sara Sepe, Chiara Milanese, Cesar Payan-Gomez, Cintia R. Bombardieri, Marie-Therese Armentero, Roberta Zangaglia, Claudio Pacchetti, Pier Giorgio Mastroberardino, and Fabio Blandini
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2014, Volume 1842, Number 9, Page 1385
[98]
Matthew Redmann, Matthew Dodson, Michaël Boyer-Guittaut, Victor Darley-Usmar, and Jianhua Zhang
The International Journal of Biochemistry & Cell Biology, 2014, Volume 53, Page 127
[99]
Michaël Boyer-Guittaut, Laura Poillet, Qiuli Liang, Elodie Bôle-Richard, Xiaosen Ouyang, Gloria A Benavides, Fatima-Zahra Chakrama, Annick Fraichard, Victor M Darley-Usmar, Gilles Despouy, Michèle Jouvenot, Régis Delage-Mourroux, and Jianhua Zhang
Autophagy, 2014, Volume 10, Number 6, Page 986
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Bartosz Szczesny, Katalin Módis, Kazunori Yanagi, Ciro Coletta, Sophie Le Trionnaire, Alexis Perry, Mark E. Wood, Matthew Whiteman, and Csaba Szabo
Nitric Oxide, 2014, Volume 41, Page 120
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Norris I. Hollie, James G. Cash, M. Abdul Matlib, Matthew Wortman, Joshua E. Basford, William Abplanalp, and David Y. Hui
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2014, Volume 1841, Number 6, Page 888
[102]
Anna-Liisa Levonen, Bradford G. Hill, Emilia Kansanen, Jianhua Zhang, and Victor M. Darley-Usmar
Free Radical Biology and Medicine, 2014, Volume 71, Page 196
[103]
Vladimir Klichko, Barbara H. Sohal, Svetlana N. Radyuk, William C. Orr, and Rajindar S. Sohal
Biochemical Journal, 2014, Volume 459, Number 1, Page 127
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Alfonso Schiavi and Natascia Ventura
Experimental Gerontology, 2014, Volume 56, Page 147
[105]
Joshua K Salabei, Andrew A Gibb, and Bradford G Hill
Nature Protocols, 2014, Volume 9, Number 2, Page 421
[106]
Philip A. Kramer, Saranya Ravi, Balu Chacko, Michelle S. Johnson, and Victor M. Darley-Usmar
Redox Biology, 2014, Volume 2, Page 206
[107]
William Dott, Pratibha Mistry, Jayne Wright, Kelvin Cain, and Karl E Herbert
Redox Biology, 2014, Volume 2, Page 224
[108]
Pamela Boon Li Pun, Angela Logan, Victor Darley-Usmar, Balu Chacko, Michelle S. Johnson, Guang W. Huang, Sebastian Rogatti, Tracy A. Prime, Carmen Methner, Thomas Krieg, Ian M. Fearnley, Lesley Larsen, David S. Larsen, Katja E. Menger, Yvonne Collins, Andrew M. James, G.D. Kishore Kumar, Richard C. Hartley, Robin A.J. Smith, and Michael P. Murphy
Free Radical Biology and Medicine, 2014, Volume 67, Page 437
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Shih-Hao Huang, Kuo-Sheng Huang, Chu-Hung Yu, and Hong-Yi Gong
Biomicrofluidics, 2013, Volume 7, Number 6, Page 064107
[110]
Samir M. Parikh
Current Opinion in Critical Care, 2013, Volume 19, Number 6, Page 554
[111]
Qiuli Liang, Gloria A. Benavides, Athanassios Vassilopoulos, David Gius, Victor Darley-Usmar, and Jianhua Zhang
Biochemical Journal, 2013, Volume 454, Number 2, Page 249
[112]
Jessica L. Fetterman, Blake R. Zelickson, Larry W. Johnson, Douglas R. Moellering, David G. Westbrook, Melissa Pompilius, Melissa J. Sammy, Michelle Johnson, Kimberly J. Dunham-Snary, Xuemei Cao, Wayne E. Bradley, Jinju Zhang, Chih-Chang Wei, Balu Chacko, Theodore G. Schurr, Robert A. Kesterson, Louis J. Dell’italia, Victor M. Darley-Usmar, Danny R. Welch, and Scott W. Ballinger
Biochemical Journal, 2013, Volume 455, Number 2, Page 157
[113]
Gloria A. Benavides, Qiuli Liang, Matthew Dodson, Victor Darley-Usmar, and Jianhua Zhang
Free Radical Biology and Medicine, 2013, Volume 65, Page 1215
[114]
Matthew Dodson, Victor Darley-Usmar, and Jianhua Zhang
Free Radical Biology and Medicine, 2013, Volume 63, Page 207
[115]
Balu K Chacko, Philip A Kramer, Saranya Ravi, Michelle S Johnson, Robert W Hardy, Scott W Ballinger, and Victor M Darley-Usmar
Laboratory Investigation, 2013, Volume 93, Number 6, Page 690
[116]
Colin Reily, Tanecia Mitchell, Balu K. Chacko, Gloria A. Benavides, Michael P. Murphy, and Victor M. Darley-Usmar
Redox Biology, 2013, Volume 1, Number 1, Page 86

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