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Thomas, Douglas D.

Biological Chemistry

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Volume 393, Issue 6 (Jun 2012)


Ubiquilins in the crosstalk among proteolytic pathways

Dong Yun Lee
  • Department of Microbial Pathogenesis, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA
/ Eric J. Brown
  • Department of Microbial Pathogenesis, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA
  • Email:


Protein degradation occurs through several distinct proteolytic pathways for membrane and cytosolic proteins. There is evidence that these processes are linked and that crosstalk among these major protein degradation pathways occurs. Ubiquilins, a family of ubiquitin-binding proteins, are involved in all protein degradation pathways. This minireview provides an overview of ubiquilin function in protein degradation and contrasts it with sequestosome-1 (p62), a protein that also has been implicated in multiple proteolytic pathways.

Keywords: autophagy; lysosome; p62; proteasome

About the article

Corresponding author

Received: 2012-02-11

Accepted: 2012-03-21

Published in Print: 2012-06-01

Citation Information: , ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/hsz-2012-0120. Export Citation

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