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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred

12 Issues per year


IMPACT FACTOR 2017: 3.022

CiteScore 2017: 2.81

SCImago Journal Rank (SJR) 2017: 1.562
Source Normalized Impact per Paper (SNIP) 2017: 0.705

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1437-4315
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Volume 393, Issue 9

Issues

Adipose triglyceride lipase in immune response, inflammation, and atherosclerosis

Branislav Radovic
  • Institute of Molecular Biology and Biochemistry, Center of Molecular Medicine, Medical University of Graz, Harrachgasse 21, A-8010 Graz, Austria
  • Other articles by this author:
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/ Elma Aflaki
  • Institute of Molecular Biology and Biochemistry, Center of Molecular Medicine, Medical University of Graz, Harrachgasse 21, A-8010 Graz, Austria
  • Present address: National Human Genome Research Institute/NIH Molecular Neurogenetics Section, 35 Convent Drive, Bethesda, MD, USA.
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Dagmar Kratky
  • Corresponding author
  • Institute of Molecular Biology and Biochemistry, Center of Molecular Medicine, Medical University of Graz, Harrachgasse 21, A-8010 Graz, Austria
  • Email
  • Other articles by this author:
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Abstract

Consistent with its central importance in lipid and energy homeostasis, lipolysis occurs in essentially all tissues and cell types, including macrophages. The hydrolytic cleavage of triacylglycerol by adipose triglyceride lipase (ATGL) generates non-esterified fatty acids, which are subsequently used as essential precursors for lipid and membrane synthesis, mediators in cell signaling processes or as energy substrate in mitochondria. This review summarizes the current knowledge concerning the consequences of ATGL deficiency in macrophages with particular emphasis on macrophage (dys)-function, apoptosis, and atherosclerosis.

Keywords: apoptosis; lipolysis; lipotoxicity; macrophages; mouse model; triacylglycerol mobilization

About the article

Corresponding author


Received: 2012-05-07

Accepted: 2012-05-23

Published in Print: 2012-09-01


Citation Information: , Volume 393, Issue 9, Pages 1005–1011, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/hsz-2012-0192.

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