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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred


IMPACT FACTOR 2017: 3.022

CiteScore 2017: 2.81

SCImago Journal Rank (SJR) 2017: 1.562
Source Normalized Impact per Paper (SNIP) 2017: 0.705

Online
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1437-4315
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Volume 394, Issue 1

Issues

Multifunctional silica nanoparticles for optical and magnetic resonance imaging

Rajendra Joshi
  • Corresponding author
  • High-Field Magnetic Resonance Center, Max Planck Institute for Biological Cybernetics, Spemannstrasse 41, D-72076 Tübingen, Germany
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/ Verena Feldmann
  • Institute of Inorganic Chemistry, University of Tübingen, Auf der Morgenstelle 18, D-72076 Tübingen, Germany
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/ Wolfgang Koestner
  • Pediatric Hematology and Oncology, Hannover Medical School, Carl-Neuberg-Strasse 1, D-30625 Hannover, Germany
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/ Claudia Detje
  • Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Feodor-Lynen-Straβe 7, D-30625 Hannover, Germany
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/ Sven Gottschalk
  • High-Field Magnetic Resonance Center, Max Planck Institute for Biological Cybernetics, Spemannstrasse 41, D-72076 Tübingen, Germany
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/ Hermann A. Mayer
  • Institute of Inorganic Chemistry, University of Tübingen, Auf der Morgenstelle 18, D-72076 Tübingen, Germany
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/ Martin G. Sauer
  • Pediatric Hematology and Oncology, Hannover Medical School, Carl-Neuberg-Strasse 1, D-30625 Hannover, Germany
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/ Jörn Engelmann
  • Corresponding author
  • High-Field Magnetic Resonance Center, Max Planck Institute for Biological Cybernetics, Spemannstrasse 41, D-72076 Tübingen, Germany
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Published Online: 2012-12-04 | DOI: https://doi.org/10.1515/hsz-2012-0251

Abstract

The surface of spherical, nonporous silica nanoparticles (SiO2-NPs) was modified with gadolinium (Gd) complexes, fluorophores, and cell-penetrating peptides to achieve multifunctionality on a single particle. The Gd surface concentrations were 9–16 μmol/g resulting in nanomaterials with high local longitudinal and transversal relaxivities (~1×105 and ~5×105 /mm/s/NP, respectively). Rapid cellular uptake was observed in vitro; however, larger extracellular agglomerates were also formed. In vivo administration revealed a fast distribution throughout the body followed by a nearly complete disappearance of fluorescence in all organs except the lungs, liver, and spleen after 24 h. Such NPs have the potential to serve as efficient multimodal probes in molecular imaging.

Keywords: contrast agents; fluorescence imaging; magnetic resonance imaging; octaarginine; SiO2 nanoparticles; surface modification

About the article

Corresponding authors: Rajendra Joshi and Jörn Engelmann, High-Field Magnetic Resonance Center, Max Planck Institute for Biological Cybernetics, Spemannstrasse 41, D-72076 Tübingen, Germany


Received: 2012-07-12

Accepted: 2012-08-09

Published Online: 2012-12-04

Published in Print: 2013-01-01


Citation Information: Biological Chemistry, Volume 394, Issue 1, Pages 125–135, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/hsz-2012-0251.

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