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Publicly Available Published by De Gruyter January 8, 2013

Microcompartments within the yeast plasma membrane

  • Hans Merzendorfer

    Hans Merzendorfer studied Biology from 1988 to 1993 at the University of Munich, where he earned his doctorate in 1999 working on insect v-type ATPases. From 1999 to 2001 Hans Merzendorfer continued his work as a Postdoc at the University of Osnabrück. In 2001 he became assistant professor, and in 2006 he obtained his “Habilitation” in animal physiology. In 2007 he received a Heisenberg fellowship from the German Research Foundation. From 2008 to 2009 he joined the Department of Biochemistry at the Kansas State University. Since 2009 Hans Merzendorfer works as an adjunct (apl.) professor at the University of Osnabrück.

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    and Jürgen J. Heinisch

    Jürgen Heinisch studied Biology at the University of Darmstadt and earned his PhD in 1985 working on yeast phosphofructokinase genetics. After a two-year postdoc (1986–1988) at the University of Alberta (Edmonton, Canada) he became a research assistant at the University of Düsseldorf and got his “Habilitation” in Microbiology in 1993. From 2000–2002 he held a professorship in Fermentation Technology at the University of Hohenheim and since 2003 is a full professor and head of the Department of Genetics at the University of Osnabrück.

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From the journal Biological Chemistry

Abstract

Recent research in cell biology makes it increasingly clear that the classical concept of compartmentation of eukaryotic cells into different organelles performing distinct functions has to be extended by microcompartmentation, i.e., the dynamic interaction of proteins, sugars, and lipids at a suborganellar level, which contributes significantly to a proper physiology. As different membrane compartments (MCs) have been described in the yeast plasma membrane, such as those defined by Can1 and Pma1 (MCCs and MCPs), Saccharomyces cerevisiae can serve as a model organism, which is amenable to genetic, biochemical, and microscopic studies. In this review, we compare the specialized microcompartment of the yeast bud neck with other plasma membrane substructures, focusing on eisosomes, cell wall integrity-sensing units, and chitin-synthesizing complexes. Together, they ensure a proper cell division at the end of mitosis, an intricately regulated process, which is essential for the survival and proliferation not only of fungal, but of all eukaryotic cells.


Corresponding authors: Hans Merzendorfer, Department of Biology/Chemistry, University of Osnabrück, Animal Physiology, Barbarastr. 11, 49076 Osnabrück, Germany; and Jürgen J. Heinisch, Department of Biology/Chemistry, University of Osnabrück, Genetics, Barbarastr. 11, 49076 Osnabrück, Germany

About the authors

Hans Merzendorfer

Hans Merzendorfer studied Biology from 1988 to 1993 at the University of Munich, where he earned his doctorate in 1999 working on insect v-type ATPases. From 1999 to 2001 Hans Merzendorfer continued his work as a Postdoc at the University of Osnabrück. In 2001 he became assistant professor, and in 2006 he obtained his “Habilitation” in animal physiology. In 2007 he received a Heisenberg fellowship from the German Research Foundation. From 2008 to 2009 he joined the Department of Biochemistry at the Kansas State University. Since 2009 Hans Merzendorfer works as an adjunct (apl.) professor at the University of Osnabrück.

Jürgen J. Heinisch

Jürgen Heinisch studied Biology at the University of Darmstadt and earned his PhD in 1985 working on yeast phosphofructokinase genetics. After a two-year postdoc (1986–1988) at the University of Alberta (Edmonton, Canada) he became a research assistant at the University of Düsseldorf and got his “Habilitation” in Microbiology in 1993. From 2000–2002 he held a professorship in Fermentation Technology at the University of Hohenheim and since 2003 is a full professor and head of the Department of Genetics at the University of Osnabrück.

Received: 2012-6-28
Accepted: 2012-8-7
Published Online: 2013-01-08
Published in Print: 2013-02-01

©2013 by Walter de Gruyter Berlin Boston

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