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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred

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1437-4315
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Volume 394, Issue 2

Issues

Dynamics of bioenergetic microcompartments

Karin B. Busch
  • Mitochondrial Dynamics, University of Osnabrück, D-49069 Osnabrück, Germany
  • These authors contributed equally to this article.
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Gabriele Deckers-Hebestreit
  • Microbiology, University of Osnabrück, D-49069 Osnabrück, Germany
  • These authors contributed equally to this article.
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Guy T. Hanke
  • Corresponding author
  • Plant Physiology, School of Biology/Chemistry, University of Osnabrück, D-49069 Osnabrück, Germany
  • These authors contributed equally to this article.
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Armen Y. Mulkidjanian
  • School of Physics, University of Osnabrück, D-49069 Osnabrück, Germany
  • A.N. Belozersky Institute of Physico-Chemical Biology, M.V. Lomonosov Moscow State University, 119992 Moscow, Russia
  • School of Bioengineering and Bioinformatics, M.V. Lomonosov Moscow State University, 119992 Moscow, Russia
  • These authors contributed equally to this article.
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2013-01-08 | DOI: https://doi.org/10.1515/hsz-2012-0254

Abstract

The vast majority of life on earth is dependent on harvesting electrochemical potentials over membranes for the synthesis of ATP. Generation of membrane potential often relies on electron transport through membrane protein complexes, which vary among the bioenergetic membranes found in living organisms. In order to maximize the efficient harvesting of the electrochemical potential, energy loss must be minimized, and this is achieved partly by restricting certain events to specific microcompartments, on bioenergetic membranes. In this review we will describe the characteristics of the energy-converting supramolecular structures involved in oxidative phosphorylation in mitochondria and bacteria, and photophosphorylation. Efficient function of electron transfer pathways requires regulation of electron flow, and we will also discuss how this is partly achieved through dynamic re-compartmentation of the membrane complexes into different supercomplexes. In addition to supercomplexes, the supramolecular structure of the membrane, and in particular the role of water layers on the surface of the membrane in the prevention of wasteful proton escape (and therefore energy loss), is discussed in detail. In summary, the restriction of energetic processes to specific microcompartments on bioenergetic membranes minimizes energy loss, and dynamic rearrangement of these structures allows for regulation.

Keywords: bacterial bioenergetics; chloroplast; microcompartment; mitochondria; OXPHOS; photosynthetic electron transfer; proton motive force; supercomplex

About the article

Karin B. Busch

Karin Busch, born 1967, studied Biochemistry, Biology and Chemistry at the University of Tuebingen/Germany. Since her PhD thesis her research focus are mitochondria, starting with the regulation of respiration in plant mitochondria. During her PhD she was holder of a stipend of the Studienstiftung des Deutschen Volkes. She spent two years as a postdoc with Hillel Fromm at the Weizmann Institute of Science/Israel followed by a postdoc at the University of Frankfurt/Germany with Robert Tampé on TIRF-based single molecule analysis. Following, she intensified her knowledge on mitochondria in living cells and high resolution microscopy in the group of Juergen Bereiter-Hahn at the University of Frankfurt/Germany. Since 2010 she is Juniorprofessor for Mitochondrial Dynamics at the University of Osnabrueck/Germany. Her research interests are the localization and dynamics of protein complexes in the inner mitochondrial membrane in the context of structure and function of mitochondria.

Gabriele Deckers-Hebestreit

Gabriele Deckers-Hebestreit, born 1956, studied biology at the Ruhr-Universität Bochum/Germany. She finished her PhD in 1986 at the Universität Osnabrück/Germany with Prof. Dr. Karlheinz Altendorf. During her PhD studies she was a stipend of the Studienstiftung des deutschen Volkes. Since 1987 she is working as a research assistant in the Department of Microbiology, University of Osnabrück (Prof. Dr. Karlheinz Altendorf; since 2010 Prof. Dr. Michael Hensel). Since 2005 she is a project leader with research interests on the distribution and dynamics of Escherichia coli ATP synthase in the cytoplasmic membrane and on the assembly of a heteromultimeric, membranebound enzyme complex using ATP synthase as a model system.

Guy T. Hanke

Guy Hanke completed his PhD in plant physiology with Mike Emes and Caroline Bowsher at the University of Manchester in 1999. He then did short post-doctoral studies at the University of Cambridge, UK, Osaka University, Japan and the University of Manchester, UK. In 2002 he started a post-doc, and then an Assistant Professorship in the laboratory of Toshiharu Hase at the Institute for Protein Research, Osaka University, Japan. During this time he became fascinated by the regulation of electron partitioning in photosynthesis, and still focuses his research on this area. Since 2008 he has been a Principal Investigator in the Department of Plant Physiology, headed by Professor Renate Scheibe at the University of Osnabrück, Germany.

Armen Y. Mulkidjanian

Armen Y. Mulkidjanian received his academic degrees from the Lomonosov Moscow State University, Russia (PhD in 1984 and Dr. Sc. in 2006) and the University of Osnabrueck, Germany (Dr. rer. nat. habil. in Biophysics, 2002). He is currently a Principal Investigator at the University of Osnabrueck, a Professor at the School of Bioengineering and Bioinformatics of the Lomonosov Moscow State University and a Senior Investigator at the A. N. Belozerky Institute of Physico-Chemical Biology of the same university. The research of Armen Mulkidjanian is focused on the molecular mechanisms of biological energy conversion and their evolution.


Corresponding author: Guy T. Hanke, Plant Physiology, School of Biology/Chemistry, University of Osnabrück, D-49069 Osnabrück, Germany


Received: 2012-07-16

Accepted: 2012-10-18

Published Online: 2013-01-08

Published in Print: 2013-02-01


Citation Information: Biological Chemistry, Volume 394, Issue 2, Pages 163–188, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/hsz-2012-0254.

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