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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred


IMPACT FACTOR 2018: 3.014
5-year IMPACT FACTOR: 3.162

CiteScore 2018: 3.09

SCImago Journal Rank (SJR) 2018: 1.482
Source Normalized Impact per Paper (SNIP) 2018: 0.820

Online
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1437-4315
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Volume 394, Issue 3

Issues

Tissue kallikrein, blood pressure regulation, and hypertension: insight from genetic kallikrein deficiency

Louis Potier
  • INSERM U872, Centre de Recherche des Cordeliers, 15 rue de l’Ecole de Medecine, F-75006 Paris, France
  • Paris-Descartes University
  • Pierre et Marie Curie University
  • Paris-Diderot University
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Ludovic Waeckel
  • INSERM U872, Centre de Recherche des Cordeliers, 15 rue de l’Ecole de Medecine, F-75006 Paris, France
  • Paris-Descartes University
  • Pierre et Marie Curie University
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Christine Richer
  • INSERM U872, Centre de Recherche des Cordeliers, 15 rue de l’Ecole de Medecine, F-75006 Paris, France
  • Paris-Descartes University
  • Pierre et Marie Curie University
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Ronan Roussel
  • INSERM U872, Centre de Recherche des Cordeliers, 15 rue de l’Ecole de Medecine, F-75006 Paris, France
  • Paris-Descartes University
  • Pierre et Marie Curie University
  • Paris-Diderot University
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Nadine Bouby
  • INSERM U872, Centre de Recherche des Cordeliers, 15 rue de l’Ecole de Medecine, F-75006 Paris, France
  • Paris-Descartes University
  • Pierre et Marie Curie University
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Francois Alhenc-Gelas
  • Corresponding author
  • INSERM U872, Centre de Recherche des Cordeliers, 15 rue de l’Ecole de Medecine, F-75006 Paris, France
  • Paris-Descartes University
  • Pierre et Marie Curie University
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2013-02-02 | DOI: https://doi.org/10.1515/hsz-2012-0332

Abstract

Tissue kallikrein has been suggested to be involved in blood pressure regulation and in protection against hypertension. However, this hypothesis remains debated. Recently, murine genetic models of kallikrein deficiency have been engineered and partial genetic deficiency in kallikrein activity has been characterized in humans. Studies in kallikrein-deficient mice indicate that kallikrein indeed influences blood pressure in the setting of mineralocorticoid excess and salt retention but not in normotensive animals and in high renin hypertension. These observations suggest that kallikrein can have antihypertensive function in physiological situations where sodium retention can trigger blood pressure elevation.

Keywords: bradykinin; epithelial sodium channel; hyperaldosteronism; renal artery obstruction; sodium retention; transgenic mice

About the article

Corresponding author: Francois Alhenc-Gelas, INSERM U872; Paris-Descartes University; and Pierre et Marie Curie University, Centre de Recherche des Cordeliers, 15 rue de l’Ecole de Medecine, F-75006 Paris, France


Received: 2012-11-19

Accepted: 2012-12-29

Published Online: 2013-02-02

Published in Print: 2013-03-01


Citation Information: Biological Chemistry, Volume 394, Issue 3, Pages 329–333, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/hsz-2012-0332.

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