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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred

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Volume 394, Issue 4


Hydroxylase-dependent regulation of the NF-κB pathway

Carsten C. Scholz
  • Systems Biology Ireland and School of Medicine and Medical Science and the Conway Institute, University College Dublin, Dublin 4, Ireland
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Cormac T. Taylor
  • Corresponding author
  • Systems Biology Ireland and School of Medicine and Medical Science and the Conway Institute, University College Dublin, Dublin 4, Ireland
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  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2013-02-28 | DOI: https://doi.org/10.1515/hsz-2012-0338


Hypoxia is associated with a diverse range of physiological and pathophysiological processes, including development, wound healing, inflammation, vascular disease and cancer. The requirement that eukaryotic cells have for molecular oxygen as the terminal electron acceptor for the electron transport chain means that the maintenance of oxygen delivery is key for bioenergetic homeostasis. Metazoans have evolved an effective way to adapt to hypoxic stress at the molecular level through a transcription factor termed the hypoxia inducible factor. A family of oxygen-sensing hydroxylases utilizes molecular oxygen as a co-substrate for the hydroxylation of hypoxia inducible factor α subunits, thereby reducing its expression and transcriptional activity when oxygen is available. Recent studies have indicated that other hypoxia-responsive transcriptional pathways may also be hydroxylase-dependent. In this review, we will discuss the role of hydroxylases in the regulation of NF-κB, a key regulator of immunity and inflammation. Developing our understanding of the role of hydroxylases in hypoxic inflammation may identify novel therapeutic approaches in chronic inflammatory disease.

Keywords: hydroxylase; hypoxia-inducible factor (HIF); NF-κB

About the article

Carsten C. Scholz

Prof. Cormac Taylor leads the Hypoxia Research Group at the Conway Institute, University College Dublin, Ireland. This group is concerned with investigating the mechanisms underpinning the cellular responses to hypoxia and hypercapnia in the context of chronic inflammatory diseases such as Inflammatory Bowel Disease.

Cormac T. Taylor

Dr. Carsten Scholz, originally from Bremen, Germany, is a postdoctoral fellow in the Hypoxia Research Group and Systems Biology Ireland.

Corresponding author: Cormac T. Taylor, Systems Biology Ireland and School of Medicine and Medical Science and the Conway Institute, University College Dublin, Dublin 4, Ireland

Received: 2012-11-26

Accepted: 2013-01-11

Published Online: 2013-02-28

Published in Print: 2013-04-01

Citation Information: Biological Chemistry, Volume 394, Issue 4, Pages 479–493, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/hsz-2012-0338.

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