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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred

IMPACT FACTOR 2018: 3.014
5-year IMPACT FACTOR: 3.162

CiteScore 2018: 3.09

SCImago Journal Rank (SJR) 2018: 1.482
Source Normalized Impact per Paper (SNIP) 2018: 0.820

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Volume 394, Issue 4


Pan-genomic binding of hypoxia-inducible transcription factors

Johannes Schödel
  • Corresponding author
  • Department of Nephrology and Hypertension, Friedrich-Alexander-University Erlangen-Nuremberg, Ulmenweg 18, D-91054 Erlangen, Germany
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/ David Robert Mole
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Published Online: 2013-02-28 | DOI: https://doi.org/10.1515/hsz-2012-0351


Hypoxia-inducible transcription factors (HIFs) mediate the cellular response to hypoxia. HIF-DNA binding triggers a transcriptional program that acts to both restore oxygen homeostasis and adapt cells to low oxygen availability. In this context, HIF is centrally involved in many physiologic and pathophysiological processes such as development, high altitude adaptation, ischemic disease, inflammation, and cancer. The recent development of chromatin immunoprecipitation coupled to genome-wide DNA sequence analysis allows the position and extent of HIF binding to DNA to be characterized across the entire genome and correlated with genetic, epigenetic, and transcriptional analyses. This review summarizes recent pan-genomic analyses of HIF binding and HIF-dependent transcriptional regulation.

Keywords: ChIP-Seq; HIF; hypoxia; transcriptional regulation

About the article

Corresponding author: Johannes Schödel, Department of Nephrology and Hypertension, Friedrich-Alexander-University Erlangen-Nuremberg, Ulmenweg 18, D-91054 Erlangen, Germany

Received: 2012-12-12

Accepted: 2012-12-22

Published Online: 2013-02-28

Published in Print: 2013-04-01

Citation Information: Biological Chemistry, Volume 394, Issue 4, Pages 507–517, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/hsz-2012-0351.

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