Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred


IMPACT FACTOR 2018: 3.014
5-year IMPACT FACTOR: 3.162

CiteScore 2018: 3.09

SCImago Journal Rank (SJR) 2018: 1.482
Source Normalized Impact per Paper (SNIP) 2018: 0.820

Online
ISSN
1437-4315
See all formats and pricing
More options …
Volume 394, Issue 5

Issues

Structure of caa3 cytochrome c oxidase – a nature-made enzyme-substrate complex

Mohamed Radzi Noor
  • Department of Chemical and Environmental Sciences and Materials and Surface Science Institute (MSSI), University of Limerick, Limerick, Ireland
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Tewfik Soulimane
  • Corresponding author
  • Department of Chemical and Environmental Sciences and Materials and Surface Science Institute (MSSI), University of Limerick, Limerick, Ireland
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2013-02-11 | DOI: https://doi.org/10.1515/hsz-2012-0343

Abstract

Aerobic respiration, the energetically most favorable metabolic reaction, depends on the action of terminal oxidases that include cytochrome c oxidases. The latter forms a part of the heme-copper oxidase superfamily and consists of three different families (A, B, and C types). The crystal structures of all families have now been determined, allowing a detailed structural comparison from evolutionary and functional perspectives. The A2-type oxidase, exemplified by the Thermus thermophilus caa3 oxidase, contains the substrate cytochrome c covalently bound to the enzyme complex. In this article, we highlight the various features of caa3 enzyme and provide a discussion of their importance, including the variations in the proton and electron transfer pathways.

Keywords: ba3 oxidase; caa3 oxidase; respiratory complex; subunit IV; terminal oxidase; Thermus thermophilus

About the article

Mohamed Radzi Noor

After completing an undergraduate degree at the University of Liverpool (UK), Mohamed Noor graduated with a PhD from the University of Limerick (Ireland) in 2012. The thesis encompasses the bioenergetics of thermophilic Thermus thermophilus in comparison to mesophiles, was performed under the tutelage of Dr. Tewfik Soulimane, and was funded by the Irish Research Council. Since then, he joined the same research group as a postdoctoral researcher investigating membrane proteins involved in bioenergetics and ion transport by incorporating X-ray crystallography and time-resolved spectroscopy.

Tewfik Soulimane

Priv. Doz. Dr Tewfik Soulimane graduated with a PhD from the RWTH-Aachen in 1993 and was awarded with the venia legendi in 2001 from the same university. He was then appointed as a senior scientist at the Paul Scherrer Institut in Villigen, Switzerland, and joined the University of Limerick in 2005 as a senior lecturer and researcher. Dr. Soulimane’ s research is concerned with bioenergetics at extreme temperature as well as investigation of the structure and function of selected secondary transporters and ion channels.


Corresponding author: Tewfik Soulimane, Department of Chemical and Environmental Sciences and Materials and Surface Science Institute (MSSI), University of Limerick, Limerick, Ireland


Received: 2012-12-02

Accepted: 2013-02-05

Published Online: 2013-02-11

Published in Print: 2013-05-01


Citation Information: Biological Chemistry, Volume 394, Issue 5, Pages 579–591, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/hsz-2012-0343.

Export Citation

©2013 by Walter de Gruyter Berlin Boston.Get Permission

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[2]
Killian Patton-Rivera, James Beck, Kenmond Fung, Christine Chan, Matthew Beck, Hiroo Takayama, and Koji Takeda
Perfusion, 2018, Page 026765911877767
[3]
Damien Finn, Peter M. Kopittke, Paul G. Dennis, and Ram C. Dalal
Soil Biology and Biochemistry, 2017, Volume 111, Page 176
[4]
Arnulf Kletzin, Thomas Heimerl, Jennifer Flechsler, Laura van Niftrik, Reinhard Rachel, and Andreas Klingl
Frontiers in Microbiology, 2015, Volume 6

Comments (0)

Please log in or register to comment.
Log in