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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred

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IMPACT FACTOR 2017: 3.022

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1437-4315
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Volume 394, Issue 5

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Recent advances in the electrochemistry and spectroelectrochemistry of membrane proteins

Frederic Melin
  • Laboratoire de Bioélectrochimie et Spectroscopie, UMR 7140, Chimie des systèmes complexes – CSC, Université de Strasbourg, 1 Rue Blaise Pascal, 67008 Strasbourg, France
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Petra Hellwig
  • Corresponding author
  • Laboratoire de Bioélectrochimie et Spectroscopie, UMR 7140, Chimie des systèmes complexes – CSC, Université de Strasbourg, 1 Rue Blaise Pascal, 67008 Strasbourg, France
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Published Online: 2013-01-28 | DOI: https://doi.org/10.1515/hsz-2012-0344

Abstract

Integral membrane proteins are encountered in fundamental natural processes, such as photosynthesis and respiration. The relation between the structure of the proteins and their function and dynamics are still not clear in most cases. Once fully understood, these processes could ultimately help researchers to develop alternative methods for producing energy, either from light or biomass. They could also lead to more efficient antibiotics, which would selectively inhibit a specific membrane protein of pathogenic bacteria. Since the chemical reactions involved in both photosynthesis and respiration are redox reactions, electrochemical methods can play a considerable role in uncovering their mechanisms. The electrochemical characterization of membrane proteins is, however, quite challenging. An overview on the techniques used for the characterization of membrane proteins, including classical approaches such as voltammetry and spectroelectrochemistry, and recent developments, such as their combination with surface-enhanced techniques is given.

Keywords: bioelectrochemistry; bioenergetics; membrane proteins; spectroelectrochemistry

About the article

Frederic Melin

Frederic Melin was born in 1976 near Paris, France. He received his PhD from the Université de Strasbourg in 2005 under the supervision of Dr. Jean Weiss. After post-doctoral studies with Prof. Luis Echegoyen in Clemson University (USA) and Dr. Fabrice Odobel in Université de Nantes (France) he moved back to Strasbourg as a ‘Maítre de Conférences’. His main research interests deal with the vibrational spectroscopy and electrochemistry of nanoparticles and proteins assemblies.

Petra Hellwig

Petra Hellwig was born in 1970 in Dortmund, Germany. She received her diploma in Chemistry in 1995 and a PhD from the Friedrich Alexander Universität Erlangen in 1998. After postdoctoral studies at the University of Illinois at Urbana Champaign (USA) and at the University of Frankfurt (Germany), she habilitated in 2002 in the biophysics department at the University of Frankfurt. Since 2006 she is full Professor of Physical Chemistry at the University of Strasbourg in France. In 2007 she was awarded a Chaire d’Excellence and since 2011 she is a member of the Institute Universitaire de France (IUF). Her main research interests include the study of the reaction mechanism of proteins on a molecular level using vibrational spectroscopies including the far infrared and Raman, as well as coupled electrochemical approaches.


Corresponding author: Petra Hellwig, Laboratoire de Bioélectrochimie et Spectroscopie, UMR 7140, Chimie des systèmes complexes – CSC, Université de Strasbourg, 1 Rue Blaise Pascal, 67008 Strasbourg, France


Received: 2012-12-03

Accepted: 2013-01-08

Published Online: 2013-01-28

Published in Print: 2013-05-01


Citation Information: Biological Chemistry, Volume 394, Issue 5, Pages 593–609, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/hsz-2012-0344.

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