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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred


IMPACT FACTOR 2018: 3.014
5-year IMPACT FACTOR: 3.162

CiteScore 2018: 3.09

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1437-4315
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Volume 394, Issue 7

Issues

Galectins: new agonists of platelet activation

Mirta Schattner
  • Corresponding author
  • Laboratory of Experimental Thrombosis, Institute of Experimental Medicine (IMEX/CONICET), National Academy of Medicine, C1425, Buenos Aires, Argentina
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Gabriel A. Rabinovich
  • Laboratory of Immunopathology, Institute of Biology and Experimental Medicine (IBYME/CONICET), C1428, Buenos Aires, Argentina
  • Laboratory of Structural and Functional Glycomics, School of Exact and Natural Sciences, University of Buenos Aires, C1428, Buenos Aires, Argentina
  • Other articles by this author:
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Published Online: 2013-03-18 | DOI: https://doi.org/10.1515/hsz-2013-0108

Abstract

Platelet activation at sites of vascular injury leads to the formation of a hemostatic plug and is crucial for hemostasis. However, uncontrolled platelet activation may lead to the formation of occlusive thrombi. Several soluble or matricellular proteins can activate platelets. In this article, we review recent advances in knowledge of the role of galectins in platelet physiology. In soluble or immobilized form, these endogenous glycan-binding proteins trigger platelet activation through the modulation of discrete signaling pathways. We discuss the role of platelet–galectin interactions not only in hemostasis, but also in chronic inflammation, atherosclerosis and cancer.

Keywords: atherosclerosis; cancer; galectins; hemostasis; inflammation; platelets

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About the article

Corresponding author: Mirta Schattner, Laboratory of Experimental Thrombosis, Institute of Experimental Medicine (IMEX/CONICET), National Academy of Medicine, C1425, Buenos Aires, Argentina


Received: 2013-01-11

Accepted: 2013-03-14

Published Online: 2013-03-18

Published in Print: 2013-07-01


Citation Information: Biological Chemistry, Volume 394, Issue 7, Pages 857–863, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/hsz-2013-0108.

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