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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred

IMPACT FACTOR 2018: 3.014
5-year IMPACT FACTOR: 3.162

CiteScore 2018: 3.09

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Volume 394, Issue 9


Synthesis of a novel benzodifuran derivative and its molecular recognition of poly rA RNA

Giovanni N. Roviello / Valentina Roviello / Domenica Musumeci
  • Dipartimento di Scienze Chimiche, Università di Napoli “Federico II”, I-80126 Napoli, Italy
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Carlo Pedone
Published Online: 2013-05-29 | DOI: https://doi.org/10.1515/hsz-2013-0154


In this manuscript, we describe a synthetic approach to a novel benzodifuran derivative as well as CD studies regarding its ability to interact with DNA and RNA. After the chemical synthesis and ESI-MS and NMR characterization, this heteroaromatic molecule was investigated by CD spectroscopy in order to evaluate it as a potential nucleic acid binder. Interestingly, the benzodifuran compound was found to be able to induce conformational changes in both DNA and RNA homoadenine molecules forming in the latter case a complex with a 6:1 benzodifuran/nucleobase stoichiometric ratio, as evidenced by CD titration experiments.

Keywords: benzodifuran; CD; RNA


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About the article

Corresponding author: Giovanni N. Roviello, Istituto di Biostrutture e Bioimmagini, CNR, Via Mezzocannone 16, I-80134 Napoli, Italy

Received: 2013-03-26

Accepted: 2013-05-28

Published Online: 2013-05-29

Published in Print: 2013-09-01

Citation Information: Biological Chemistry, Volume 394, Issue 9, Pages 1235–1239, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/hsz-2013-0154.

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