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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred


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Volume 395, Issue 10

Issues

Inflammatory outcomes of apoptosis, necrosis and necroptosis

Pavel Davidovich
  • Cellular Biotechnology Laboratory, Saint-Petersburg State Institute of Technology, Moskovskii prospekt, St. Petersburg, Russia
  • Other articles by this author:
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/ Conor J. Kearney
  • Molecular Cell Biology Laboratory, Department of Genetics, The Smurfit Institute, Trinity College, Dublin 2, Ireland
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/ Seamus J. Martin
  • Corresponding author
  • Cellular Biotechnology Laboratory, Saint-Petersburg State Institute of Technology, Moskovskii prospekt, St. Petersburg, Russia
  • Molecular Cell Biology Laboratory, Department of Genetics, The Smurfit Institute, Trinity College, Dublin 2, Ireland
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Published Online: 2014-08-05 | DOI: https://doi.org/10.1515/hsz-2014-0164

Abstract

Microbial infection and tissue injury are well established as the two major drivers of inflammation. However, although it is widely accepted that necrotic cell death can trigger or potentiate inflammation, precisely how this is achieved still remains relatively obscure. Certain molecules, which have been dubbed ‘damage-associated molecular patterns’ (DAMPs) or alarmins, are thought to promote inflammation upon release from necrotic cells. However, the precise nature and relative potency of DAMPs, compared to conventional pro-inflammatory cytokines or pathogen-associated molecular patterns (PAMPs), remains unclear. How different modes of cell death impact on the immune system also requires further clarification. Apoptosis has long been regarded as a non-inflammatory or even anti-inflammatory mode of cell death, but recent studies suggest that this is not always the case. Necroptosis is a programmed form of necrosis that is engaged under certain conditions when caspase activation is blocked. Necroptosis is also regarded as a highly pro-inflammatory mode of cell death but there has been little explicit examination of this issue. Here we discuss the inflammatory implications of necrosis, necroptosis and apoptosis and some of the unresolved questions concerning how dead cells influence inflammatory responses.

Keywords: alarmins; apoptosis; cell death; danger; damage-associated molecular patterns; inflammation; necrosis; necroptosis

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About the article

Corresponding author: Seamus J. Martin, Cellular Biotechnology Laboratory, Saint-Petersburg State Institute of Technology, Moskovskii prospekt, St. Petersburg, Russia; and Molecular Cell Biology Laboratory, Department of Genetics, The Smurfit Institute, Trinity College, Dublin 2, Ireland, e-mail:


Received: 2014-03-13

Accepted: 2014-08-01

Published Online: 2014-08-05

Published in Print: 2014-10-01


Citation Information: Biological Chemistry, Volume 395, Issue 10, Pages 1163–1171, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/hsz-2014-0164.

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