Abstract
The cyclophilin family of peptidyl prolyl cis/trans isomerases includes several isoforms found to be secreted in response to different stimuli, thus existing both in the interior and the exterior of cells. The extracellular fractions of the cyclophilins CypA and CypB are involved in the control of cell-cell communication. By binding to the cell membrane receptor CD147 and cell surface heparans they elicit a variety of intracellular signaling cascades involved in inflammatory processes. Increased levels of cyclophilins in inflammatory tissues and body fluids are considered as an inflammatory response to injury. Thus, the extracellular portion of cyclophilins probably plays an important role in human diseases associated with acute or chronic inflammation like rheumatoid arthritis, sepsis, asthma and cardiovascular diseases. Specific inhibition of the cyclophilins in the extracellular space may open an effective therapeutic approach for treating inflammatory diseases.
About the authors
Henrik Hoffmann studied Biology at the Martin Luther University Halle-Wittenberg. Currently, he works on his PhD thesis about the regulation of RNA binding cyclophilins.
Cordelia Schiene-Fischer studied Biochemistry at the Martin Luther University Halle-Wittenberg, where she received her PhD for an analysis of the catalysis of native state isomerization in proteins in 1999. After performing postdoctoral work in Halle, she continued her work about foldases as leader of an independent research group at the Max Planck Research Unit for Enzymology of Protein Folding in Halle. Currently, she works at the Institute of Biochemistry at the Martin Luther University Halle-Wittenberg.
Acknowledgments
The work was supported by the Deutsche Forschungsgemeinschaft GRK 1026.
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