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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

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Volume 396, Issue 11


Hepatitis C virus and autophagy

Linya Wang
  • Department of Molecular Microbiology and Immunology, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Jing-hsiung James Ou
  • Corresponding author
  • Department of Molecular Microbiology and Immunology, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2015-05-29 | DOI: https://doi.org/10.1515/hsz-2015-0172


Autophagy is a catabolic process by which cells remove protein aggregates and damaged organelles for recycling. It can also be used by cells to remove intracellular microbial pathogens, including viruses, in a process known as xenophagy. However, many viruses have developed mechanisms to subvert this intracellular antiviral response and even use this pathway to support their own replications. Hepatitis C virus (HCV) is one such virus and is an important human pathogen that can cause severe liver diseases. Recent studies indicated that HCV could activate the autophagic pathway to support its replication. This review summarizes the current knowledge on the interplay between HCV and autophagy and how this interplay affects HCV replication and host innate immune responses.

Keywords: autolysosomes; autophagosomes; autophagy; hepatitis C virus; innate immunity; unfolded protein response


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About the article

Corresponding author: Jing-hsiung James Ou, Department of Molecular Microbiology and Immunology, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA, e-mail:

Received: 2015-05-02

Accepted: 2015-05-26

Published Online: 2015-05-29

Published in Print: 2015-11-01

Citation Information: Biological Chemistry, Volume 396, Issue 11, Pages 1215–1222, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/hsz-2015-0172.

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