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Biological Chemistry

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Volume 396, Issue 5


Incidence and physiological relevance of protein thiol switches

Lars I. Leichert
  • Corresponding author
  • Ruhr-Universität Bochum, Institute of Biochemistry and Pathobiochemistry – Microbial Biochemistry, Universitätsstr. 150, D-44780 Bochum, Germany
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Tobias P. Dick
  • Corresponding author
  • Division of Redox Regulation, DKFZ-ZMBH Alliance, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2015-02-25 | DOI: https://doi.org/10.1515/hsz-2014-0314


A few small-molecule oxidants, most notably hydrogen peroxide, can act as messengers in signal transduction. They trigger so-called ‘thiol switches’, cysteine residues that are reversibly oxidized to transiently change the functional properties of their host proteins. The proteome-wide identification of functionally relevant ‘thiol switches’ is of significant interest. Unfortunately, prediction of redox-active cysteine residues on the basis of surface accessibility and other computational parameters appears to be of limited use. Proteomic thiol labeling approaches remain the most reliable strategy to discover new thiol switches in a hypothesis-free manner. We discuss if and how genomic knock-in strategies can help establish the physiological relevance of a ‘thiol switch’ on the organismal level. We conclude that surprisingly few attempts have been made to thoroughly verify the physiological relevance of thiol-based redox switches in mammalian model organisms.

Keywords: cysteine; redox signaling; thiol switches


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About the article

Corresponding authors: Lars I. Leichert, Ruhr-Universität Bochum, Institute of Biochemistry and Pathobiochemistry – Microbial Biochemistry, Universitätsstr. 150, D-44780 Bochum, Germany, e-mail: ; and Tobias P. Dick, Division of Redox Regulation, DKFZ-ZMBH Alliance, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany, e-mail:

Received: 2014-12-14

Accepted: 2015-02-21

Published Online: 2015-02-25

Published in Print: 2015-05-01

Citation Information: Biological Chemistry, Volume 396, Issue 5, Pages 389–399, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/hsz-2014-0314.

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