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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred

IMPACT FACTOR 2018: 3.014
5-year IMPACT FACTOR: 3.162

CiteScore 2018: 3.09

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Source Normalized Impact per Paper (SNIP) 2018: 0.820

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Volume 396, Issue 6-7


Sphingolipids in liver injury, repair and regeneration

Hiroyuki Nojima
  • Department of Surgery, University of Cincinnati College of Medicine, 231 Albert Sabin Way, ML 0558, Cincinnati, OH 45267-0558, USA
  • Other articles by this author:
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/ Christopher M. Freeman
  • Department of Surgery, University of Cincinnati College of Medicine, 231 Albert Sabin Way, ML 0558, Cincinnati, OH 45267-0558, USA
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/ Erich Gulbins
  • Department of Surgery, University of Cincinnati College of Medicine, 231 Albert Sabin Way, ML 0558, Cincinnati, OH 45267-0558, USA
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/ Alex B. Lentsch
  • Corresponding author
  • Department of Surgery, University of Cincinnati College of Medicine, 231 Albert Sabin Way, ML 0558, Cincinnati, OH 45267-0558, USA
  • Email
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  • De Gruyter OnlineGoogle Scholar
Published Online: 2015-03-12 | DOI: https://doi.org/10.1515/hsz-2014-0296


Sphingolipids are not only essential components of cellular membranes but also function as intracellular and extracellular mediators that regulate important physiological cellular processes including cell survival, proliferation, apoptosis, differentiation, migration and immune responses. The liver possesses the unique ability to regenerate after injury in a complex manner that involves numerous mediators, including sphingolipids such as ceramide and sphingosine 1-phosphate. Here we present the current understanding of the involvement of the sphingolipid pathway and the role this pathway plays in regulating liver injury, repair and regeneration. The regulation of sphingolipids and their enzymes may have a great impact in the development of novel therapeutic modalities for a variety of liver injuries and diseases.

Keywords: ceramide; liver injury; liver regeneration; sphingolipids; sphingosine 1-phosphate


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About the article

Corresponding author: Alex B. Lentsch, Department of Surgery, University of Cincinnati College of Medicine, 231 Albert Sabin Way, ML 0558, Cincinnati, OH 45267-0558, USA, e-mail:

Received: 2014-12-04

Accepted: 2015-03-09

Published Online: 2015-03-12

Published in Print: 2015-06-01

Citation Information: Biological Chemistry, Volume 396, Issue 6-7, Pages 633–643, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/hsz-2014-0296.

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