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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred

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Volume 396, Issue 6-7

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The effect of altered sphingolipid acyl chain length on various disease models

Woo-Jae Park
  • Department of Biochemistry, School of Medicine, Gachon University, Incheon 406-799, South Korea
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Joo-Won Park
  • Corresponding author
  • Department of Biochemistry, School of Medicine, Ewha Womans University, Seoul 158-710, South Korea
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2015-01-24 | DOI: https://doi.org/10.1515/hsz-2014-0310

Abstract

Sphingolipids have emerged as an important lipid mediator in intracellular signalling and metabolism. Ceramide, which is central to sphingolipid metabolism, is generated either via a de novo pathway, by attaching fatty acyl CoA to a long-chain base, or via a salvage pathway, by degrading pre-existing sphingolipids. As a ‘sphingolipid rheostat’ has been proposed, the balance between ceramide and sphingosine-1-phosphate has been the object of considerable attention. Ceramide has recently been reported to have a different function depending on its acyl chain length: six ceramide synthases (CerS) determine the specific ceramide acyl chain length in mammals. All CerS-deficient mice generated to date show that sphingolipids with defined acyl chain lengths play distinct pathophysiological roles in disease models. This review describes recent advances in understanding the associations of CerS with various diseases and includes clinical case reports.

Keywords: acyl chain length; ceramide synthase; disease; sphingolipid

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About the article

Corresponding author: Joo-Won Park, Department of Biochemistry, School of Medicine, Ewha Womans University, Seoul 158-710, South Korea, e-mail:


Received: 2014-12-12

Accepted: 2015-01-21

Published Online: 2015-01-24

Published in Print: 2015-06-01


Citation Information: Biological Chemistry, Volume 396, Issue 6-7, Pages 693–705, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/hsz-2014-0310.

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