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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

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Volume 396, Issue 9-10


A universal mechanism for transport and regulation of CPA sodium proton exchangers

Octavian Călinescu
  • Department of Biophysical Chemistry, Max Planck Institute of Biophysics, Max-von-Laue-Str. 3, D-60438 Frankfurt/Main, Germany
  • Department of Biophysics, Faculty of Medicine, ‘Carol Davila’ University of Medicine and Pharmacy, RO-050474 Bucharest, Romania
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Klaus Fendler
  • Corresponding author
  • Department of Biophysical Chemistry, Max Planck Institute of Biophysics, Max-von-Laue-Str. 3, D-60438 Frankfurt/Main, Germany
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2015-01-28 | DOI: https://doi.org/10.1515/hsz-2014-0278


Recent studies performed on a series of Na+/H+ exchangers have led us to postulate a general mechanism for Na+/H+ exchange in the monovalent cation/proton antiporter superfamily. This simple mechanism employs a single binding site for which both substrates compete. The developed kinetic model is self-regulatory, ensuring down-regulation of transport activity at extreme pH, and elegantly explains the pH-dependent activity of Na+/H+ exchangers. The mechanism was experimentally verified and shown to describe both electrogenic and electroneutral exchangers. Using a small number of parameters, exchanger activity can be modeled under different conditions, providing insights into the physiological role of Na+/H+ exchangers.

Keywords: cation/proton antiporter superfamily; Na+/H+ exchangers; NhaA; NhaP1; pH regulation; transport mechanism


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About the article

Corresponding author: Klaus Fendler, Department of Biophysical Chemistry, Max Planck Institute of Biophysics, Max-von-Laue-Str. 3, D-60438 Frankfurt/Main, Germany, e-mail:

Received: 2014-11-28

Accepted: 2015-01-26

Published Online: 2015-01-28

Published in Print: 2015-09-01

Citation Information: Biological Chemistry, Volume 396, Issue 9-10, Pages 1091–1096, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/hsz-2014-0278.

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