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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred

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Volume 396, Issue 9-10 (Sep 2015)

Issues

The assembly and disassembly of the AcrAB-TolC three-component multidrug efflux pump

Reinke Tobias Müller / Klaas Martinus Pos
Published Online: 2015-06-09 | DOI: https://doi.org/10.1515/hsz-2015-0150

Abstract

In Gram-negative bacteria, tripartite efflux pumps, like AcrAB-TolC from Escherichia coli, play a prominent role in the resistance against multiple antibiotics. Transport of the drugs across the outer membrane and its coupling to the electrochemical gradient is dependent on the presence of all three components. As the activity of the E. coli AcrAB-TolC efflux pump is dependent on both the concentration of substrates and the extent of the electrochemical gradient across the inner membrane, the dynamics of tripartite pump assembly and disassembly might be crucial for effective net transport of drugs towards the outside of the cell.

Keywords: antibiotic resistance; proton-motive force; transport; tripartite efflux pumps

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About the article

Corresponding author: Klaas Martinus Pos, Institute of Biochemistry, Goethe University Frankfurt, D-60438 Frankfurt/Main, Germany, e-mail:


Received: 2015-03-31

Accepted: 2015-06-03

Published Online: 2015-06-09

Published in Print: 2015-09-01


Citation Information: Biological Chemistry, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/hsz-2015-0150.

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