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Licensed Unlicensed Requires Authentication Published by De Gruyter September 9, 2015

Correlated overexpression of metadherin and SND1 in glioma cells

  • Liping Tong , Chao Wang , Xuebin Hu , Bo Pang , Zhonghui Yang , Zhangxiu He , Meihui He , Lanlan Wei EMAIL logo and Ming Chu EMAIL logo
From the journal Biological Chemistry

Abstract

Glioma is the most common primary brain tumor with poor prognosis. Effective treatment of glioma remains a big challenge due to complex pathogenic mechanisms. Previous studies have shown that metadherin (MTDH) and its interacting protein staphylococcal nuclease domain containing 1 (SND1) are overexpressed in many solid tumors. To elucidate the role of MDTH and SND1 in the pathogenesis of glioma, we examined the expression of MTDH and SND1 in primary glioma tissues and found that both MTDH and SND1 were highly expressed, with similar expression patterns. Co-expression of MTDH and SND1 was associated with advanced glioma grades. In addition, we detected the interaction between MTDH and SND1 in cultured glioma cell lines. MTDH could promote the expression of p65 and SND1 in glioma cells. However, enhanced SND1 expression by MTDH was abolished by the inhibition of p65. In conclusion, we demonstrated high expression levels MTDH and SND1 in primary glioma tissues. MTDH might promote glioma by inducing SND1 expression through the activation of NF-κB pathway. MTDH and SND1 may serve as the indicator of malignancy and prognosis as well as therapeutic targets for patients with glioma.

Keywords: glioma; MTDH; NF-κB; SND1

Corresponding authors: Lanlan Wei, Department of Microbiology, Harbin Medical University, Immunity and Infection, Pathogenic Biology Key Laboratory in Heilongjiang Province, 150081 Harbin, China, e-mail: ; and Ming Chu, Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, 150001 Harbin, China, e-mail:

Acknowledgments

This work was supported by the Key Project of Chinese Ministry of Education (No. 212043), the Scientific Research Foundation for ROCS, SEM. (No. 2011-508), and Heilongjiang Provincial Science and Technology Innovation Team in Higher Education Institute for Infection and Immunity.

Conflicts of interest statement: The authors declare no conflict of interest.

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Received: 2015-5-6
Accepted: 2015-9-4
Published Online: 2015-9-9
Published in Print: 2016-1-1

©2016 by De Gruyter

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