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Biological Chemistry

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Volume 398, Issue 2


The novel class of seven transmembrane segment inverted repeat carriers

Yung-Ning Chang
  • Institute of Biochemistry, Biocenter, Goethe University Frankfurt, Max-von-Laue-Str. 9, D-60438 Frankfurt am Main, Germany
  • Other articles by this author:
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/ Eric R. Geertsma
  • Corresponding author
  • Institute of Biochemistry, Biocenter, Goethe University Frankfurt, Max-von-Laue-Str. 9, D-60438 Frankfurt am Main, Germany
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Published Online: 2016-11-19 | DOI: https://doi.org/10.1515/hsz-2016-0254


Solute carriers from the SLC4, SLC23, and SLC26 families are involved in pH regulation, vitamin C transport and ion homeostasis. While these families do not share any obvious sequence relationship, they are united by their unique and novel architecture. Each member of this structural class is organized into two structurally related halves of seven transmembrane segments each. These halves span the membrane with opposite orientations and form an intricately intertwined structure of two inverted repeats. This review highlights the general design principles of this fold and reveals the diversity between the different families. We discuss their domain architecture, structural framework and transport mode and detail an initial transport mechanism for this fold inferred from the recently solved structures of different members.

Keywords: anion exchanger; inverted repeat; nucleobase ascorbate transporter; nucleobase cation symporter-2; solute carrier family; sulfate permease


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About the article

Received: 2016-07-18

Accepted: 2016-11-16

Published Online: 2016-11-19

Published in Print: 2017-02-01

Citation Information: Biological Chemistry, Volume 398, Issue 2, Pages 165–174, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/hsz-2016-0254.

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