Jump to ContentJump to Main Navigation
Show Summary Details
More options …

New Journal!

Biomedical Glasses

Editor-in-Chief: Boccaccini, Aldo R.

1 Issue per year

Open Access
Online
ISSN
2299-3932
See all formats and pricing
More options …

Opening paper 2015- Some comments on Bioglass: Four Eras of Discovery and Development

Larry L. Hench
Published Online: 2015-06-09 | DOI: https://doi.org/10.1515/bglass-2015-0001

Abstract

Historically the function of biomaterials was to replace diseased or damaged tissues. First generation biomaterials were selected to be as bio-inert as possible and thereby minimize formation of scar tissue at the interface with host tissues. Bioactive glasseswere discovered in 1969 and provided for the first time an alternative; strong, stable interfacial bonding of an implant with host tissues. In the 1980’s it was discovered that bioactive glasses could be used in particulae form to stimulate osteogenesiswhich thereby led to the concept of regeneration of tissues. This article summarizes the four eras of development of bioactive glasses that have led from concept of bioactivity to widespread clinical and commercial use, with emphasis on the first composition, 45S5 Bioglassr. The four eras are; A) Era of Discovery, B) Era of Clinical Application, C) Era of Tissue Regeneration, and D) Era of Innovation. Key scientific and technological questions answered for the first three eras are presented. Questions still to be answered for the fourth era are included to stimulate innovation in the field.

References

  • [1] L.L. Hench, R.J. Splinter, W.C. Allen, and T.K. Greenlee, Jr. Bonding Mechanisms at the Interface of Ceramic Prosthetic Materials, J. Biomed. Maters. Res. 2Google Scholar

  • [1] (1971), 117-141 . Google Scholar

  • [2] C.A. Beckham, T.K. Greenlee Jr. and A.R. Crebo, Jr Bone Formation at a Ceramic Implant Interface, Calc.Tissue Res. 8, 165 (1971) Google Scholar

  • [3] T.K. Greenlee Jr., C.A. Beckham, A.R. Crebo and J.C. Malmborg, Glass Ceramic Bone Implants, J. Biomed. Mater. Res. 6 (1972), 235-244 Google Scholar

  • [4] L.L. Hench and H.A. Paschall., Direct Chemical Bonding of Bioactive Glass-Ceramic Materials and Bone, J. Biomed. Mats. Res. Symp. No. 4 (1973), 25-42. CrossrefGoogle Scholar

  • [5] L.L. Hench and H.A. Paschall , Histo-Chemical Responses at a Biomaterials Interface, J. Biomed. Mats. Res. No. 5 (Part 1) (1974), 49-64. Google Scholar

  • [6] G. Piotrowski, L.L. Hench,W.C. Allen and G.J. Miller, Mechanical Studies of the Bone-Bioglass Interfacial Bond, J. Biomed.Mater. Res. Symp. 9Google Scholar

  • [4] (1975), 47-61. Google Scholar

  • [7] L.L. Hench, H.A. Paschall, W.C. Allen and G. Piotrowski, Interfacial Behavior of Ceramics Implants, National Bureau of Standards Special Publication 415, May 1975, 19-35. Google Scholar

  • [8] A.E. Clark, L.L. Hench and H.A. Paschall, The Influence of Surface Chemistry on Implant Interface Histology: A Theoretical Basis for Implant Materials Selection, J. Biomed. Maters. Res. 10 (1976), 161-174. Google Scholar

  • [9] L.L. Hench and A.E. Clark, Adhesion to Bone, in Biocompatibility of Orthopaedic Implants, D.F. Williams and G.D. Winter, eds., CRC Press. Boca Raton, Florida, Vol. II, 1982, Chapter 6. Google Scholar

  • [10] J. Wilson, G.H. Pigott, F.J. Schoen, and L.L. Hench, Toxicology and Biocompatibility of Bioglass, J. Biomed.Mater. Res. 15, 805 (1981). Google Scholar

  • [11] L.L. Hench, The story of Bioglass, J. Mater. Sci: Mater Med. 17 (2006), 967-978. CrossrefGoogle Scholar

  • [12] L.L. Hench, June W. Hench and D.C. Greenspan, Bioglass: A Short History and Bibliography, J. Aust. Ceram. Soc. 40[1] (2004), 1-42. Google Scholar

  • [13] L.L. Hench, Bioceramics: From Concept to Clinic, J. Am. Ceram. Soc. 74Google Scholar

  • [7] (1991), 1487-1510. Google Scholar

  • [14] L.L. Hench, Bioceramics., J. Am. Ceram. Soc. 81[7] (1998), 1705- 28. Google Scholar

  • [15] I.D. Xynos, M.V.J. Hukkanen, J.J. Batten, I.D. Buttery, L.L. Hench and J.M. Polak, Bioglassr45S5 Stimulates Osteoblast Turnover and Enhances Bone Formation In Vitro: Implications and Applications for Bone Tissue Engineering., Calcif. Tiss. Int. 67: 321- 329 (2000) Google Scholar

  • [16] L.L. Hench, J.M. Polak, I.D. Xynos and L.D.K. Buttery, Bioactive Materials to Control Cell Cycle, Mat. Res. Innovat. 3:313-323 (2000). CrossrefGoogle Scholar

  • [17] I.D. Xynos, A.J. Edgar, L.D. Buttery, L.L. Hench and J.M. Polak, Ionic Dissolution Products of Bioactive Glass Increase Proliferation of Human Osteoblasts and Induce Insulin-like Growth Factor II mRNA Expression and Protein Synthesis, Biochem. Biophys. Res. Comm. 276: 461-465 (2000). Google Scholar

  • [18] I.D. Xynos, A.J. Edgar, L.D.K. Buttery, L.L. Hench and J.M. Polak, Gene Expression Profiling of Human Osteoblasts Following Treatment with the Ionic Dissolution Products of Bioglassr 45S5 Dissolution, J. Biomed. Mater. Res. 55: 151-157 (2001). Google Scholar

  • [19] L.L. Hench, I.D. Xynos, A.J. Edgar, L.D.K. Buttery, J.M. Polak, J.P. Zhong, X.Y. Liu and J. Chang, Gene Activating Glasses, Journal of Inorganic Materials 17 (2002), 897-909. Google Scholar

  • [20] L.L. Hench, Glass and Genes: The 2001 W.E.S. Turner Memorial Lecture, Glass Technology 44 (2003), 1-10. Google Scholar

  • [21] L.L. Hench, Characterization of Glass Corrosion and Durability, J. Non-Crystalline Solids 19 (1975) 27-39. Google Scholar

  • [22] A.E. Clark Jr., C.G. Pantano Jr. and L.L. Hench, Auger Spectroscopic Analysis of Bioglass Corrosion Films, J. Am. Ceram. Soc. 59Google Scholar

  • [1-2] (1976), 37-39. Google Scholar

  • [23] Cheol Y. Kim, A.E. Clark and L.L. Hench, Early Stages of Calcium- Phosphate Layer Formation in Bioglass, J. Non-Crystalline Solids 113 (1989), 195-202. Google Scholar

  • [24] L.L. Hench and D.E. Clark, Physical Chemistry of Glass Surfaces, J. Non-Crystalline Solids 28[1] (1978), 83-105. Google Scholar

  • [25] L.L. Hench, ed, An Introduction to Bioceramics-Second Edition, chapters 6,7,8,9,10,11,12, 31, Imperial College Press, London, (2013) Google Scholar

  • [26] H.R. Stanley, L.L. Hench, C.G. Bennett Jr., S.J. Chellemi, C.J. King III, R.E. Going, N.J. Ingersoll, E.C. Ethridge, K.L. Kreutziger, L. Loeb and A.E. Clark, The Implantation of Natural Tooth Form Bioglassr in Baboons - Long Term Results, Intern. J. Oral Implantology, 2 (1981), 26-36. Google Scholar

  • [27] Gerald E. Merwin, James S. Atkins, June Wilson, Larry L. Hench, Comparison of Ossicular ReplacementMaterials in a Mouse Ear Model, Otolaryngol. Head Neck Surg. 90 (1982) 461-469. Google Scholar

  • [28] June Wilson, J.S. Atkins, G.E. Merwin and L.L. Hench, Histopathological Evaluation of Interaction between Tympanic Membrane and ImplantMaterials, Trans. Soc. For Biomat. Vol.8 195, 1985 Google Scholar

  • [29] G. Merwin, L. Rogers, June Wilson and R. Martin, Facial Bone Augmentation using Bioglassrin Dogs., Arch. Otolaryngology, Head and Neck Surgery., Vol. 112, 280-285, 198 Google Scholar

  • [30] G.E. Merwin, Bioglassr middle ear prosthesis: preliminary report, Ann. Otol. Rhinol. Laryngol. 95; 1 Pt 1:78-82 January- February (1986). Google Scholar

  • [31] K. Lobel, Ossicular Replacement Prostheses, in Clinical Performance of Skeletal Prostheses, Hench and Wilson (eds), Chapman and Hall, Ltd, London, (1996), pp. 214-236 Google Scholar

  • [32] P. Griss, D.C. Greenspan, G. Heimke, B. Krempien, R. Buchinger, L.L. Hench and G. Jentschura, Evaluation of a Bioglass Coated Al2O3 Total Hip Prosthesis in Sheep, J. Biomed. Maters. Res. 10Google Scholar

  • [4] (1976), 511-518. Google Scholar

  • [33] O.H. Andersson, G. Liu, K. Kangasniemi and J. Juhanjoa, Evaluation of the Acceptance of Glass in Bone, 1. Maters. Sci., Maters. in Med. 3 (1992), 145-150. Google Scholar

  • [34] N.C. Lindfors, J.T. Heikkila, I. Koski, K. Mattila and A.J. Aho, Bioactive glass and autogenous bone as bone graft substitutes in benign bone tumors., J. Biomed. Mater. Res. B. Appl. Biomater., 90 (2009), 131-6. Google Scholar

  • [35] J. McAndrew, C. Efrimescu, E. Sheehan and D. Niall, Through the looking glass; bioactive glass S53P4 (BonAliver ) in the treatment of chronic osteomyelitis., Ir. J. Med. Sci., 182 (2013), 509- 11. Google Scholar

  • [36] K. Pernaa, I. Koski, K. Mattila, E. Gullichsen, Heikkila J, Aho A, Lindfors N. Bioactive glass S53P4 and autograft bone in treatment of depressed tibial plateau fractures - a prospective randomized 11-year follow-up, J Long Term Eff Med Implants 21 (2011), 139-48. Google Scholar

  • [37] J. Sarin, R. Grenman, K. Aitasalo and J. Pulkkinen, Bioactive glass S53P4 in mastoid obliteration surgery for chronic otitis media and cerebrospinal fluid leakage, Ann. Otol. Rhinol. Laryngol. 121 (2012), 563-9. Google Scholar

  • [38] T. Kokubo, S. Ito, S. Sakka and T. Yamamuro, Formation of a High-Strength Bioactive Glass - Ceramic in the System MgOCaO- SiO2-P2O5, J. Mater. Sci. 21, 536 (1986). CrossrefGoogle Scholar

  • [39] T. Yamamuro, A/W Glass-Ceramics: Clinical Applications, Introduction to Bioceramics, 2nd Edition, L.L. Hench, ed, Imperial College Press, Chapter 14, 189-208 (2013). Google Scholar

  • [40] H.R. Stanley, Alveolar Ridge maintenance using endosseously placed Bioglass (45S5) Cones, Encyclopedic, Handbook of Biomaterials and Bioengineering; Part B: Applications Volume 2, D.L. Wise et al. (eds), (1995) Marcel Dekker Inc, New York, NY, pp. 1559-1616 Google Scholar

  • [41] H.R.Stanley, A.E. Clark and L.L. Hench, Alveolar Ridge Maintenance Implants, Clinical Performance of Skeletal Prostheses, L.L. Hench and JuneWilson, Eds. Chapman and Hall, Publishers, London, England, (1995) 255-270 Google Scholar

  • [42] M.B. Hall, H.R. Stanley, C. King, F. Colaizzi, D. Spilman and L.L. Hench, Early Clinical Trials of 45S5 Bioglassr for Endosseous Ridge Maintenance with a New Endosseous Implant Material, J. Prosthetic Dentistry, 58[5] (1987), 607-613 Google Scholar

  • [43] Harold R. Stanley, Matthew B. Hall, Arthur E. Clark, Caleb J. King III and Larry L. Hench, Joseph J. Berte, Using 45S5 Bioglass §Cones as Endosseous Ridge Maintenance Implants to Prevent Alveolar Ridge Resorption: A 5-Year Evaluation, Int. J. Oral Maxillofac. Implants, 12 (1997), 95-105. Google Scholar

  • [44] JuneWilson, A.E. Clark, M. Hall and L.L. Hench, Tissue Response to Bioglassr Endosseous Ridge Maintenance Implants, J. Oral Implantology, XIXGoogle Scholar

  • [4], (1993), 295-302 Google Scholar

  • [45] A.M. Weinstein, J.J. Klawitter and S.D. Cook, Implant-bone interface characteristics of bioglass dental implants, J. Biomed. Mater. Res., 14, 1:23-9, January (1980). Google Scholar

  • [46] J. Wilson, E. Douek and K. Rust, BioglassrMiddle Ear Devices: Ten year Clinical Results, Bioceramics 8, (1995) J. Wilson, L.L. Hench and D. Greenspan, Eds. Elsevier Science, Oxford, England Google Scholar

  • [47] K.R. Rust, G.T. Singleton, J. Wilson, P.J. Antonelli, Bioglass middle ear prosthesis: long-term results, Am. J. Otol., 17 (1996), 371- 4. Google Scholar

  • [48] J. Wilson, S. Low, A. Fetner and L.L. Hench, Bioactive Materials for Periodontal Treatment: A Comparative Study, in Biomaterials and Clinical Applications, A. Pizzoferrato, P.G. Marchetti, A. Ravaglioli and A.J.C. Lee, eds., Elsevier Science Publishers, Amsterdam, (1987), 223-228. Google Scholar

  • [49] J.Wilson and S.B. Low, Bioactive Ceramics for Periodontal Treatment: Comparative Studies in the Patus Monkey, J. Appl. Biomaterials, Vol 3 (1992), 123-169 Google Scholar

  • [50] H. Oonishi, L.L. Hench, J. Wilson, F. Sugihara, E. Tsuji, S. Kushitani and H. Iwaki, Comparative Bone Growth Behaviour in Granules of BioceramicMaterials of Various Sizes, J. Biomed.Mater. Res. 44 (1999), 31-43 Google Scholar

  • [51] H. Oonishi, L.L. Hench, J. Wilson, F. Sugihara, E. Tsuji, M. Matsuwura, S. Kin, T. Yamamoto and S. Mizokawa, Quantitative Comparison of Bone Growth Behaviour in Granules in Bioglassr, A-W Glass Ceramic, and Hydroxyapatite, J. Biomed. Mater. Res. 51, (2000), 37-46. Google Scholar

  • [52] J.R. Jones, Review of bioactive glass: From Hench to Hybrids, Acta Biomater, 9[1] (2012), 4457-4486. Google Scholar

  • [53] L.L. Hench, ed, Introduction to Bioceramics, 2nd edition, Imperial Collge Press, (2013) Chapters 6,7,8,9,10,11,12,31 Google Scholar

  • [54] D. Wheeler, E.J. Eschbach, R.G. Hoellrich, M.J., Montfort, D.L. Chamberland, Assessment of resorbable bioactive material for grafting of critical-size cancellous defects, J. Orthop. Res., 2000 Jan, 18 (1): 140-8 10716290 Google Scholar

  • [55] L.L. Hench, Bioactive Glasses: Gene Expression, An Introduction to Bioceramics, 2nd edition, L.L. Hench, ed, Imperial College Press, London, (2013), chapter 4, 71-86 Google Scholar

  • [56] R.C. Bielby, I.S. Christodoulou and R.S. Pryce et al., (2004) Time and concentration-dependant effects of dissolution products of 58S sol-gel bioactive glass on proliferation and differentiation of murine and human osteoblasts, Tissue Eng. 10, 1018-1026. CrossrefGoogle Scholar

  • [57] I. Christodoulou, L.D.K. Buttery and P. Saravanapavan et al., (2005), Characterization of human fetal osteoblasts by microarray analysis following stimulation with 58S bioactive gel-glass ionic dissolution products, J. Biomed.Mater. Res. 77B, 431-446. Google Scholar

  • [58] A. Hoppe, N.S. Güldal, A.R. Boccaccini, A review of the biological response to ionic dissolution products from bioactive glasses and glass-ceramics, Biomaterials 32 (2011), 2757-2774. Google Scholar

  • [59] R.M. Day, A.R. Boccaccini, S. Shurey, J.A. Roether, A. Forbes, L.L. Hench, S.M. Gabe, Assessment of polyglycolic acid mesh and bioactive glass for soft-tissue engineering scaffolds, Biomaterials 25 (2004), 5857-5866. Google Scholar

About the article

Received: 2014-10-01

Accepted: 2015-02-13

Published Online: 2015-06-09


Citation Information: Biomedical glasses, ISSN (Online) 2299-3932, DOI: https://doi.org/10.1515/bglass-2015-0001.

Export Citation

© 2015 Larry L. Hench. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Daniela Carta, Julian R. Jones, Sen Lin, Gowsihan Poologasundarampillai, Robert J. Newport, and David M. Pickup
International Journal of Applied Glass Science, 2017
[2]
J. Rivadeneira and A. Gorustovich
Journal of Applied Microbiology, 2017, Volume 122, Number 6, Page 1424
[3]
Aldo R. Boccaccini, Michael Fenn, Julian R. Jones, Toshihiro Kasuga, M. Grant Norton, Mohammed N. Rahaman, Enrica Verné, and Edgar D. Zanotto
Journal of Materials Science, 2017, Volume 52, Number 15, Page 8691
[4]
M. V. Gonzalez Galdos, J. I. Pastore, J. Ballarre, and S. M. Ceré
Journal of Materials Science, 2017, Volume 52, Number 15, Page 9151
[5]
Víctor I. Macías-Andrés, Wei Li, Ena A. Aguilar-Reyes, Yaping Ding, Judith A. Roether, Leila Harhaus, Carlos A. León-Patiño, and Aldo R. Boccaccini
Journal of Biomedical Materials Research Part A, 2017, Volume 105, Number 6, Page 1765
[6]
Thomas Meincke, Valentina Miguez Pacheco, Daniel Hoffmann, Aldo R. Boccaccini, and Robin N. Klupp Taylor
Journal of Materials Science, 2017, Volume 52, Number 15, Page 9082
[7]
N. El Shazley, A. Hamdy, H.A. El-Eneen, R.M. El Backly, M.M. Saad, W. Essam, H. Moussa, M. El Tantawi, H. Jain, and M.K. Marei
JDR Clinical & Translational Research, 2016, Volume 1, Number 3, Page 244
[8]
Yinghong Zhou, Mengchao Shi, Julian R. Jones, Zetao Chen, Jiang Chang, Chengtie Wu, and Yin Xiao
International Materials Reviews, 2017, Volume 62, Number 7, Page 392
[9]
M. E. Galarraga-Vinueza, J. Mesquita-Guimarães, R. S. Magini, J. C. M. Souza, M. C. Fredel, and A. R. Boccaccini
Journal of Biomedical Materials Research Part A, 2017, Volume 105, Number 2, Page 672
[10]
Julian R. Jones, Delia S. Brauer, Leena Hupa, and David C. Greenspan
International Journal of Applied Glass Science, 2016, Volume 7, Number 4, Page 423
[11]
Anahí Philippart, Natividad Gómez-Cerezo, Daniel Arcos, Antonio J. Salinas, Elena Boccardi, Maria Vallet-Regi, and Aldo R. Boccaccini
Journal of Non-Crystalline Solids, 2017, Volume 455, Page 90
[12]
Kai Zheng, Miao Lu, Yufang Liu, Qiang Chen, Nicola Taccardi, Norbert Hüser, and Aldo R Boccaccini
Biomedical Materials, 2016, Volume 11, Number 3, Page 035012
[13]
Gowsihan Poologasundarampillai, Peter D. Lee, Colman Lam, Anna-Maria Kourkouta, and Julian R. Jones
International Journal of Applied Glass Science, 2016, Volume 7, Number 2, Page 229
[14]
Dominika Kozon, Kai Zheng, Elena Boccardi, Yufang Liu, Liliana Liverani, and Aldo Boccaccini
Materials, 2016, Volume 9, Number 4, Page 225
[15]
Jiaolong Wang, Lina Wang, Ziyu Zhou, Hanjian Lai, Pan Xu, Lan Liao, and Junchao Wei
Polymers, 2016, Volume 8, Number 4, Page 115
[16]
Sigrid Seuss, Marion Heinloth, and Aldo R. Boccaccini
Surface and Coatings Technology, 2016, Volume 301, Page 100
[17]
C. Ashok raja, S. Balakumar, D. Durgalakshmi, R. P. George, B. Anandkumar, and U. Kamachi Mudali
RSC Adv., 2016, Volume 6, Number 24, Page 19657
[18]
Maziar Montazerian and Edgar Dutra Zanotto
Journal of Biomedical Materials Research Part A, 2016, Volume 104, Number 5, Page 1231
[19]
Larry L. Hench and Julian R. Jones
Frontiers in Bioengineering and Biotechnology, 2015, Volume 3
[20]
Elena Boccardi, Anahí Philippart, Judith A. Juhasz-Bortuzzo, Ana M. Beltrán, Giorgia Novajra, Chiara Vitale-Brovarone, Erdmann Spiecker, and Aldo R. Boccaccini
Frontiers in Bioengineering and Biotechnology, 2015, Volume 3
[21]
Qiang Chen, Rosalina Pérez Garcia, Josemari Munoz, Uxua Pérez de Larraya, Nere Garmendia, Qingqing Yao, and Aldo R. Boccaccini
ACS Applied Materials & Interfaces, 2015, Volume 7, Number 44, Page 24715
[22]
Marta Miola, Enrica Verné, Francesca Elisa Ciraldo, Luis Cordero-Arias, and Aldo R. Boccaccini
Frontiers in Bioengineering and Biotechnology, 2015, Volume 3
[23]
[24]
Wei Li, Yaping Ding, Shanshan Yu, Qingqing Yao, and Aldo R. Boccaccini
ACS Applied Materials & Interfaces, 2015, Volume 7, Number 37, Page 20845

Comments (0)

Please log in or register to comment.
Log in