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Biomedical Glasses

Editor-in-Chief: Boccaccini, Aldo R.

CiteScore 2018: 2.05

SCImago Journal Rank (SJR) 2018: 0.424
Source Normalized Impact per Paper (SNIP) 2018: 0.562

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Zinc-containing bioactive glasses for bone regeneration, dental and orthopedic applications

Preethi Balasubramanian / Leonie A. Strobel
  • Department of Hand, Plastic and Reconstructive Surgery - Burn Center, University of Heidelberg, Ludwigshafen, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Ulrich Kneser
  • Department of Hand, Plastic and Reconstructive Surgery - Burn Center, University of Heidelberg, Ludwigshafen, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Aldo R. Boccaccini
Published Online: 2015-07-29 | DOI: https://doi.org/10.1515/bglass-2015-0006


Zinc is a vital and beneficial trace element found in the human body. Though found in small proportions, zinc performs a variety of functions in relation to the immune system, cell division, fertility and the body growth and maintenance. In particular, zinc is proven to be a necessary element for the formation, mineralization, development and maintenance of healthy bones. Considering this attractive attributes of zinc, recent research has widely focused on using zinc along with silicate-based bioactive glasses for bone tissue engineering applications. This paper reviews relevant literature discussing the significance of zinc in the human body, along with its ability to enhance antibacterial effects, bioactivity and distinct physical, structural and mechanical properties of bioactive glasses. In this context, even if the present analysis is not meant to be exhaustive and only representative studies are discussed, literature results confirm that it is essential to understand the properties of zinc-containing bioactive glasses with respect to their in vitro biological behavior, possible cytotoxic effects and degradation characteristics to be able to effectively apply these glasses in bone regeneration strategies. Topics attracting increasing research efforts in this field are elaborated in detail in this review, including a summary of the structural, physical, biological and mechanical properties of zinc-containing bioactive glasses. This paper also presents an overview of the various applications in which zinc-containing bioactive glasses are considered for use as bone tissue scaffolds, bone filling granules, bioactive coatings and bone cements, and advances and remaining challenges are highlighted.

Keywords: Bioactive glasses; Zinc; Degradation; Dissolution; Bone Tissue Engineering


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About the article

Received: 2015-03-01

Accepted: 2015-05-25

Published Online: 2015-07-29

Citation Information: Biomedical glasses, Volume 1, Issue 1, ISSN (Online) 2299-3932, DOI: https://doi.org/10.1515/bglass-2015-0006.

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© 2015 P. Balasubramanian et al.. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0

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Materials Science and Engineering: C, 2019, Page 109910
M. D. Telgerd, Mohammad Sadeghinia, Gebremariam Birhanu, M. P. Daryasari, Ali Zandi‐Karimi, Ali Sadeghinia, Hamid Akbarijavar, M. H. Karami, and Ehsan Seyedjafari
Journal of Biomedical Materials Research Part A, 2019
Francesca Ciraldo, Kristin Schnepf, Wolfgang Goldmann, and Aldo Boccaccini
Materials, 2019, Volume 12, Number 3, Page 423
Nasrin Esfahanizadeh, Mohammad Reza Nourani, Abbas Bahador, Nasrin Akhondi, and Mostafa Montazeri
Biomedical Glasses, 2018, Volume 4, Number 1, Page 95
Faleh Abushahba, Eva Söderling, Laura Aalto-Setälä, Johan Sangder, Leena Hupa, and Timo O Närhi
Biomedical Physics & Engineering Express, 2018, Volume 4, Number 4, Page 045002
You-Min Kim, Dong-Hyun Kim, Chang Weon Song, Seog-Young Yoon, Se-Yeon Kim, Hee Sam Na, Jin Chung, Yong-Il Kim, and Yong Hoon Kwon
The Korean Journal of Orthodontics, 2018, Volume 48, Number 3, Page 163
Francesco Baino, Sepideh Hamzehlou, and Saeid Kargozar
Journal of Functional Biomaterials, 2018, Volume 9, Number 1, Page 25
Alireza Rahimnejad Yazdi, Lawrence Torkan, Stephen D. Waldman, and Mark R. Towler
Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2017
J. Rivadeneira and A. Gorustovich
Journal of Applied Microbiology, 2017, Volume 122, Number 6, Page 1424
Mei Huang, Robert G. Hill, and Simon C.F. Rawlinson
Dental Materials, 2017, Volume 33, Number 5, Page 543
L Esteban-Tejeda, B Cabal, R Torrecillas, C Prado, E Fernandez-Garcia, R López-Piriz, F Quintero, J Pou, J Penide, and J S Moya
Biomedical Materials, 2016, Volume 11, Number 4, Page 045014
A. Wajda and M. Sitarz
Journal of Non-Crystalline Solids, 2016, Volume 441, Page 66
Marta Miola, Enrica Verné, Francesca Elisa Ciraldo, Luis Cordero-Arias, and Aldo R. Boccaccini
Frontiers in Bioengineering and Biotechnology, 2015, Volume 3

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